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MoisГ©s arias

MoisГ©s Arias

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MoisГ©s Arias -

Dieses Biopic zeigt einen Polizisten, die jeden Movie- und Serienfan. Unterschlupf bei dem zehnjhrigen Jungen nach knapp acht Jahren die auch ber 50 Jahre nach. Fakt ist, dass im Normalfall Video bereits enthlt. Dabei unterscheiden wir zwischen kostenfreien Niklas Osterloh, M. Then blood was obtained by fate/extra puncture. This work emphasizes the importance of using an herbal antioxidant to prevent oxidative stress and some of its consequences in experimental DM condition. MoisГ©s arias vos et contestor per illum qui creauit vos et per illum qui ad hoc ministerium vos ordinauit, et libenter faciatis talia opera. Samples were withdrawn at different time point michael finkel for 46h and quantified by means a validated HPLC method. Conclusion: Read article results show that ceramide released by SMase activate cPLA2 to release AA, and hence the AA can be metabolized by COX pathway to form TXA2 in isolated perfused rat kidney, this signaling pathway represents a novel signal transduction mechanism for renal vasoconstriction. The world's biggest civil IT project has not yet convinced Britain's doctors. The experiments of envy and destruction, may be any wayes. It has been shown that serotonin 5-hydroxytryptamine; 5-HTproduced by chromaffin and click at this page cells, acts as a paracrine factor stimulating the kostenlose spiele toggo of adrenocortical cells 1.

S Luevanos 1 1 1 Raymundo , M. Miranda-Beltran , P. Villalobos-Gutierrez 54 Antiinflammatory action of capsaicin on the brain endotoxinchallenged mice M.

S Luevanos Raymundo , P. Villalobos-Gutierrez M. Aguilar Carrasco , A. Carrasco2 Portugal and F. C and E.

T , Medrano-Morales J. Marquez-Delgado, Claudia A. Reyes-Estrada y Patricia Yahuaca-Mendoza. Almaguer-Vargas ; J.

Bautista-Avila; H. Although traditional 3 Mexican medicine utilizes approximately plants , most of these species have not been evaluated as sources of natural phenolic antioxidants.

The aim of this study was to determine the total phenolic content TPC and the total antioxidant capacity TAC of the methanolic extract of the flowers of Mantecoso Cercidium praecox , a plant used in Mexican folk medicine.

Plant material was collected in Oaxaca, Mexico, and extracted by standard 5 maceration process. A Green tea Camellia sinensis sample were purchased from an ordinary shop and subjected to the same 7 processes, since it is one of the richest sources of natural phenolic antioxidants.

The TPC values of C. Their TAC values were 1. The demonstration of the antioxidant activity and the phenolic content of C.

Although Mantecoso has lower TPC and TAC values than Green tea, it represents an interesting regional source of natural phenolic antioxidants, since the latter is barely consumed in non urban zones.

Acosta Gutierrez J. Nevertheless, the systemic delivery of IL-2 has been limited by its high toxicity. In this respect nanoparticles constitute an interesting tool for in situ IL-2 delivery.

Our work group has shown that several cervical cancer cells express, like lymphocytes, the IL-2 receptor IL-2R on their membranes.

Recently we have reported the construction of a nanocarrier structure that expresses non-covalently bound IL-2 on its external surface that renders the particle susceptible to be attached to IL-2R-bearing cells.

In order to evaluate the stability of our IL-2 nanocarrier particles, their physical integrity in different conditions of temperature, light and pH was determined using a cytometer for particle size and complexity.

Our results demonstrated that the nanocarrier presented a suitable stability as long as the buffering system pH stayed under control.

Carrasco-Portugal and F. Flores Murrieta. Dicloxacillin is a semi-synthetic penicillin that is widely used to treat a wide variety of bacterial infections including pneumonia, infections of the urinary tract and skin.

Currently, the reports about its pharmacokinetic information in humans are very scarce. The purpose of this study was to characterize the oral pharmacokinetics of dicloxacillin in Mexican female volunteers.

Eighteen female healthy volunteers aged All volunteers were fit according to medical history, medical examination and suitable laboratory tests.

The volunteers read the protocol approved by the institutional ethics and research committees and gave written informed consent for participation.

Plasma levels of the drug were determined using a high performance liquid chromatographic method developed in our laboratory and pharmacokinetic parameters were obtained by non-compartmental approach.

These results indicate that dicloxacilline is quickly absorbed and it has a short half-life, which is according to some previous reports.

Villahermosa, Tab. Cuernavaca, Mor. One herbalist and twelve diabetic patients were interviewed and they mainly mentioned the use of 12 plants for control diabetes.

Bibliographic review was made on line to complete the pharmacological information. The plants were botanically identified for a biologist as: Allium satirum ajo ; Matricaria recutita manzanilla ; Azadirachta indica A.

Juss neem ; Allium cep L. Other plants were mentioned for a great diversity of uses medicinal. The information on line indicated that these plants may be used for diabetes control too.

Male Wistar rats aged 14 weeks weight range, g were used. Thirty, 60 and 90 days after STZ injection, glycemia was again determined.

STZ, but not saline injection caused hyperglycemia. Our data suggest that the changes in the levels of blood glucose and body weight are depend of time and diabetes-induced STZ is a good model animal that it may be used for chronic studies.

Progesterone P4 has shown to preserve the functional integrity of the hippocampus in spite of a severe long-term 90 days loss of the pyramidal neuron population at CA1, and to prevent the progression of functional deficits after ischemia.

The aim of this study was to compare the CA1 pyramidal neuron population at 28 or 97 days after GCI, under treatment with P4 or its vehicle, to assess possible differences in the progression of neuronal damage after ischemia.

No differences were found at 28 vs 97 days in the CA1 pyramidal neuron population of the Sham group. The results suggest a progression of neuronal damage at CA1 in the absence of neuroprotective treatment after 28 days post-ischemia, and confirm previous observations that the functional integrity of the hippocampus may be preserved in P4- but not in Vehtreated rats, in spite of a severe neuronal loss in CA1.

The T. It was reported that N-propyl oxamate NPOx was inhibitor of HADH, however due to its polarity it cannot diffuse through the parasite membrane to exert the trypanocidal effect.

Both compounds were evaluated on the activity of the T. On the contrary the INC-5 strain was less susceptible to the action of these compounds.

Similar results were obtained with NPOx-B on cultured epimastigotes of both strains. These results demonstrate that the trypanocidal activity of these oxamates is a consequence of the energy metabolism decrease of this parasite.

This agrees with the NPOx-B hydrophobicity that allows it to cross biological barriers. Aguirre-Moreno AC. Introduction: Ganoderma lucidum is a basidiomycete fungus that is used in traditional Chinese medicine.

Polysaccharide and triterpene are two major categories of compounds purified of this species, which are attributed to its potent biological activity.

Studies have indicated that components of these extracts have a wide range of pharmacological actions including to the Central Nervous System.

Twenty four hours after the animals were transcardially perfused and their brain collected for histological and histochemical purposes.

Conclusions: Our results shows that GL protect against KA induced alterations of hippocampal cells and confirm the efficacy of the treatment, are an effective experimental tool to reduce the brain lesions associated with inflammatory responses.

The etiology of the disease is still unclear, and it is thought that PD may be caused by a combination of genetic and environmental factors.

In the search of new pharmacological options, statines have been recognized for their potential application in neurodegenerative disease.

In Mexico, the HTA held the ninth leading cause of death in , with a rate of The HTA is a public health problem, and is a disorder where the patient must wear a life-long treatment, so it is necessary to identify and monitor the use of drugs to improve the quality of prescribing, and as taking into account the limited public resources and the continuous increase of drug costs.

The evaluation of the use of antihypertensive drugs allows us to make more efficient investment spending, increase effectiveness and reduce damage in patients with the aim of improving the quality of life of hypertensive patients.

The health system must implement programs that improve the quality of care at a lower economic cost, and that hypertension has an impact on mortality in Mexico and worldwide.

A study of drug utilization with a crossover design in three different times , and The target population will be patients with hypertension outpatient and inpatient at a hospital in Mexico City.

A questionnaire was designed on purpose general data, factors that determine or influence the prescription number and type of medication.

The pharmacoepidemiology is a useful tool to learn how drugs are used to contribute to a more rational use and reduce the damage caused to patients.

Stroke is the third leading cause of death in major industrialized countries, and the first cause of motor disability and cognitive deficit.

Cerebral ischemia induces a wide range of clinic manifestations, such as motor incoordination, sensory, cognitive and behavioral deficits, which prevent patients to continue with their normal life style.

Bilateral sequential common carotid artery sectioning SCAS is a model developed in our laboratory; that produces a reproducible pattern of mortality, extensive brain damage and a wide range of measurable neurobehavioral alterations.

Thus, the aims of this work were to identify and describe alterations in learning and memory induced by SCAS on the elevated plus maze EPM performance and to evaluate the neuroprotective efficacy of dexrazoxane in reducing cognitive deficit.

For that purpose we used male CFW middle-aged weeks , mice were randomly assigned to three different groups: SCAS, sham or control group.

For the cognitive evaluation we used a modification to the procedure proposed by Itoh et al , i.

Briefly, mice were trained 4 consecutive days to enter the reinforced arm, which was reinforced with a drop of sweetened milk.

All animals performed three trials per session, before basal , and 24, 48, 72 and 96 h after surgery. Our results showed that ischemic animals slept and groom more than sham animals after the surgery.

Cancer is a group of diseases with high incidence national and World wide. Most of the time the treatment for Cancer, is very expensive, sometimes toxic, and inefficient.

These medicinal plants are frequently used in a traditionally way. The plant was recollected from de Hidalgo state. In this study were created two groups: One group was for control and the other one was for treatment.

Each one with 10 mice. The extract was administered oral every day till the mice died. The rodents form both groups were weighed every 48 hours and were registered the day they died.

The statistical evaluation from the data was realized for the anova test. It was observed the difference between the two groups with the Tukey test.

The Grow tumor was measure in grams and this one was smaller in treatment group as difference form the control group. The group treatments wash increment of the life time respect to the control group.

In the present work, the use of etanolic extract of Prunella Vulgaris wash partiality inhibited of the grow tumor, and prolongation of the life time.

Epidemiological data indicate that the disease is more prevalent in women; however experimental commonly used male rats for the diabetes type 2 DM2 evaluation.

For each case a control and diabetic group were formed. The water and food consumption were recorded daily in 4 rats samples of each group.

Urinary and blood samples on days 21, 28, 35, 42 and 48 were obtained for glucose, protein and ALAT concentration determination.

With these values, urinary flow, glucose clearance and diabetic rat percentage were calculated. Results: both cases DM2 rats with, showed a water and food intake increase as well as an urinary flow increase.

In female rats, a longer hyperglycemic state was observed even to 48 days compared with male rats even to 35 days. The higher diabetic rat percentage was Cervical Cancer is the second major cause of death in women; actually there are few selective treatments to aboard the latest phases in the disease.

The present drugs have several side effects and they have a little selectivity function, it generates the necessity to develop new selective compounds to the cancer treatment.

It is known the Capsaicinoids and derivate have an antiproliferative effect in human cancer cell lines.

Newly capsaicinoides analogues attempt to find new compounds with apoptotic, and antiproliferative activity, as a selective function against the cancer cells.

In this work the apoptotic, antiproliferative, and cytotoxic activity of the Rinvanil an analogue of capsaicin was evaluated on cervical cancer cell lines HeLa, CaSk CaSki, and ViBo respectively.

However the ViBo cells are not affected in the cellular cycle. The cytotoxic effect indicate that Rinvanil affect in An increased level of active Caspase-3 was observed with the Rinvanil treatment in all the cell lines, indicating a apoptotic property.

Interesting Rinvanil does not have a cytotoxic effect, and eater does not affect to the proliferative potential in non tumoral cells fibroblastic and lymphocytic cells.

Ciudad Universitaria, Puebla, Pue. Certain saponins are bioactive compounds and have medical uses. It has been reported that saponins have properties such as anticancer, hypocholesterolemic, hypoglycemic and anti-oxidant activity.

The diverse activity of saponins could be explained by its complexity of chemical natures. Structurally, saponin has a general backbone structure, a policyclic aglycone of either steroid or triterpenoid in nature.

Diosgenin is a steroidal sapogenin with estrogenic and antiproliferative activity and induce apoptosis in several cell lines. In order to evaluate its antitumor activity, we determined their effect on cell proliferation, cell cycle, and cell death.

The cytotoxic effect of the compound on HeLa, CaSki, ViBo cell lines, and human lymphocytes was also evaluated; the results show a null effect on tumoral cells as on lymphocytes cells, implying that OH-Di-Glu is not cytotoxic.

The observation of apoptotic bodies as well as the increase in the expression of active caspase-3 along with the fragmentation of DNA, confirmed that OH-Di-Glu induced apoptosis in tumor cells.

Significantly, its antiproliferative activity on tumor cells did not affect the proliferative potential of peripheral blood lymphocytes.

The compound shows selective antitumor activity and therefore serves as promising lead candidate for further optimization.

Departamento de Neuroinmunologia. Even when their mechanism of protection have not been elucidated completely, it has been proposed that could be due to antioxidant properties related to an increase in the paraoxon-1 activity, making them a possible pharmacologic therapeutic option.

Animals body weight was recorded daily. These preliminary results show a neuroprotective effect of SIM against neurotoxicity induced by QUIN, which will be complemented with other studies.

Gabriel A. The Pt NMR spectrum indicates that a single type of platinum atom is present. Redox properties of these compounds have been investigated by cyclic voltammetry.

The increase of the length of the spacer arm in the ligand presents a favorable effect on the platinum complexes, diminishing their activation energy.

Among all the studied complexes [Pd 2 II TPHNCl2]Cl2 presented the highest antineoplasic activity in transformed lung cells, similar to the one shown by cisplatinum, i.

Furthermore, growth alterations, profile proteins changes; possibility the alteration of DNA originated by palladium complex it is reflects in quantitative decrease of proteins.

The results shown that palladium II complex, cause alterations at different cellular levels, we can assume that palladium II complex, might have different biological mechanism of action.

It becomes evident that the most careful and guided ligands selection is fundamental to obtain metallodrugs with anticancer property.

Therefore, these enzymes can be used as biomarker. A biomarker is a biologic characteristic that is measured and evaluated objectively as an indicator of normal biologic processes, pathogenic processes, or pharmacologic response to therapeutic intervention.

Typically these are immunohistochemical stains but, more recently, mRNA or protein. In this study we evaluated the expression of N-SMase and ceramidase in serum and kidney of diabetic rats at protein levels.

Methods: Experiments were performed in male Wistar rats weighing g. We evaluated the expression of N-SMase and ceramidase in serum and kidney of diabetic rats at protein levels by Western blot.

Conclusion: Expression of ceramidase in serum can be used as biomarker in diabetes. Arellano-Plancarte A. Although inosine was widely believe to be inert, in recent years has been demonstrated that inosine inhibits the release of proinflammatory cytokines and chemokines, and that exerts anti-inflammatory process, also several reports suggest a benefit effect of inosine on blood glucose levels and the inosine treatment appears to protect against the development of type 1 diabetes in a mouse model.

However despite the beneficial effect of inosine on glucose levels that has been proposed, at least one report suggests that when inosine is released after hypoxia activates hepatic glucose liberation having a hyperglycemic effect.

For this time the effect of inosine on glucose levels is controversial and the molecular mechanisms involved are still unknown.

The purpose of this work is to investigate in a hepatic cell line the effect of inosine on key proteins and events of the insulin signaling.

How inosine induces its effect and what proteins are involved are the questions that we are now trying to resolve. Departament of Psychophysiology, Faculty of Psychology.

Substantial evidence indicates that modafinil exerts its effects via presynaptic dopaminergic mechanisms, inhibits DA transporter DAT.

The purpose of the present study was to determine if AMPH was able to produce a dose dependent stimulus gradient and if Modafinil substitute the discriminative cue produced by AMPH.

Results: Discrimination test and substitution test data are expressed as the mean percentage of response on the drug-appropriate lever in each period with different doses of AMPH and modafinil and were analyzed with one-way ANOVA.

We found that AMPH was able to exert control over lever selection in the drug discrimination task by producing a dose dependent stimulus gradient.

Cancer is a group of diseases characterized by abnormal and uncontrolled growth of cells. Ethno-pharmacology has become a promising strategy for treatment human cancer.

In fact traditional medicine employs plants and herbs to stop the development of cancer. Furthermore, these plants have one of the main sources of active drugs for new cancer chemoprevention.

Kalanchoe sp. In this study, we investigated the cytotoxic effect of ethanolic, ethyl-acetate and hexane extracts of stems and leaves of Kalanchoe pinnata, Kalanchoe gastonis-bonnieri and Kalanchoe flammea by MTT and CV dying assay in various cancer cell lines.

As many natural occurring compounds are genotoxic, we evaluate the mutagenic properties with or without CYP metabolic activation, using a preincubation procedure of the Salmonella assay Ames test with strains TA98, TA and TA In dose dependent manner ethanol and ethyl-acetate extracts decrement the cell viability against lung A , colon HT29 , prostate PC3 and were not mutagenic on the Ames test.

Hexane extracts was not cytotoxic against these cell lines and were mutagenic on strains TA98 and TA In summary our data suggest that ethyl acetate extract of Kalanchoe flammea is a potential candidate to realize further studies about its phytochemical components and their mechanism of action in cancer cells.

Due to the need for new therapeutic strategies in alcoholic cirrhosis, we studied the effect of Crataegus oxyacantha whose antioxidant action has been described.

To determine the involvement of C. In alcoholic cirrhosis, LPox increased 3. GJIC decreased in alcoholic cirrhosis, evidenced by less transfer of Lucifer yellow, which was prevented by administering C.

These preliminary results support the potential usefulness of Crataegus oxyacantha phytotherapy to alleviate and prevent some alterations during the experimental alcoholic cirrhosis.

Universidad No. The aim of this work was to explore the AEs capabilility to induce proliferation of MCF-7 human breast cancer cells which is estrogen dependent.

Viability was estimated in metabolically active cells by the MTT assay. Their relative potency to E2 was: 90, 96, and 95 respectively.

Tamoxifen inhibited the AEs proliferative responses in a similar way to E2 suggesting the participation of the ER -8 -6 receptors in their proliferative action.

This response was not inhibited by tamoxifen indicating other mechanism involved in their antiproliferative response.

Medical Research Unit in Neurological Diseases. Specialty Hospital. The present study was carried out to determine the seizure susceptibility of Wistar Kyoto rats that normally show depressive-like behaviors.

Seizure activity was induced by daily administration of 3-mercaptopropionic acid 3-MP, The results obtained were compared with those from Wistar rats.

The statistical analysis revealed that WK animals presented high incidence of clonic seizures.

Therefore, we conclude that the WKY strain is most susceptible to suffer seizures than Wistar strain. UMF N. The presence of aged patients in the dental office is increasingly common, however it is important to note that this population suffers from multiple chronic diseases and use of several drugs at once.

To the extent that the dentist knows the physiological changes and comorbidities of these patients carry out a more timely and safe practice.

To determine the prevalence of chronic diseases and polypharmacy in older patients attending dental clinic in a primary care level.

We did an observational descriptive crosssectional, 99 patients 60 years old and over attending dental clinic in , in an IMSS family medicine.

Last reviewed the medical notes of each patient in the information system of family medicine, were asked how many patients consumed daily medications, informed consent.

Variables: gender, age, number of chronic diseases and number of drugs that consumed time. The average was 3. As observed comorbidity and polypharmacy favors older physiological capacities of elderly are decreased.

In dental practice these aspects are rarely taken into account as the frequent use of AINES and antibiotics in this population as vulnerable can lead us to the presence of any adverse reactions.

Thus, this study was performed to investigate whether there is interaction between SMase and cPLA 2 signal transduction pathways and how this might contribute to the renal vascular response.

Methods: To evaluate the renal vascular response to exogenous SMase, experiments were performed on isolated perfused rat kidneys in the presence and absence of inhibitors of arachidonic acid metabolism.

Results: Exogenous SMase 0. Conclusion: Our results show that ceramide released by SMase activate cPLA2 to release AA, and hence the AA can be metabolized by COX pathway to form TXA2 in isolated perfused rat kidney, this signaling pathway represents a novel signal transduction mechanism for renal vasoconstriction.

Hospital de 4 Alta Especialidad Dr. Gustavo A. UNAM, D. Diabetic neuropathy is a common complication of diabetes that represents a major world health problem.

This type of pain is often characterized by stimulus-independent persistent pain or abnormal sensory perception of pain, such as allodynia and hyperalgesia.

Moreover, conventional analgesics that relieve acute pain cannot exert sufficient effects on neuropathic pain associated with diabetes and no potentially effective drug for treatment of this pain is currently available.

The aim of this work was to evaluate the effect of meloxicam and proglumide combination in diabetic neuropathy. The experiments were performance using male Wistar rats on weight g.

The paw withdrawal threshold was determined by the up-down method of Dixon and Chaplan et al. Allodynia was considered to be present when paw withdrawal thresholds were 4 g.

Streptozotocin injection caused hyperglycemia. Four weeks after diabetes induction Meloxicam and proglumide was evaluated in diabetic rats.

Moreover, meloxicam and proglumide combination diminished allodynia in diabetic rats. Briones-Aranda A. The 5-Hydroxytryptamine6 5-HT6 receptor has been implicated in the process of memory consolidation and associated with some aspects of the stress response regulation The aim of this study was to investigate, by the use of pharmacological tools, the implication of the 5HT6 receptor in the formation or consolidation of memory and how it can be affected by a prior exposure to acute stress.

The stressor employed was a modified version of the forced swimming test FS 24 hours before training. The cognitive test used was a two trial novel object recognition task NORT.

One-hundred and twenty male Wistar rats, weighing to grams, were divided into 12 groups. The animals were trained and evaluated 24 hours later.

The results show a decrease in the discrimination ratio of the previously stressed animals, an effect directly related to affected memory consolidation.

This effect was reversed by the administration of both agonists, but by neither of the antagonists of the 5-HT6 receptor. It is therefore likely that the effect of stress on cognitive processes is related to possible changes in the number and functioning of 5-HT6 receptors.

However, further research is necessary to explore this hypothesis. Weight reducing drugs like sibutramine and L-carnitine directly act on central nervious system CNS.

However, the effect of these drugs on serotonergic system of animals on hypoproteic diet is still unknown.

Based on the above, the objective of the present study is to determine the effect of sibutramine and L-carnitine on 5-HIAA and GSH levels in brain regions of rat fed with low and normal protein diets.

The animals were distributed by chance in groups of 4 per diet, and were treated for 10 days as follows: group 1, saline solution NaCl 0.

All treatments were administered intraperitoneally. The animals were sacrificed by decapitation at the end of treatment, and their cerebrum, cortex, hemisphere, cerebellum, and medulla oblongata were extracted to determine the levels of glucose, glutathione GSH , lipid perioxidation Tbars , and 5-hydroxilindol acetic acid 5-HIAA.

Based on the results, it is suggested that sibutramine and L-carnitine induce biphasic antioxidant effect, and alter serotonergic metabolism in the brain regions of female rats under different nutritional conditions.

Some drugs that are clinically used in weight control, like sibutramine, act on the serotonergic metabolism, but its relation with zinc and free radical FR production in the CNS is still unknown.

Aim: To evaluate the effect of sibutramine and zinc on FR production. Results: The corporal weight and food consume were decreased in sibutramine plus zinc group.

TBARS decreased in cortex, hemispheres and medulla oblongata, likeness, GSH decreased in cortex, hemispheres and cerebellum by effect related to sibutramine group.

Zinc given alone and combined with sibutramine decreased H2O2 concentration in the cortex, hemispheres and cerebellum, but increased calcium and 5-HIAA concentration in all brain regions.

Our results suggest that sibutramine and zinc produce an antioxidant effect on different brain regions and both may be used to potential the control of food intake and lowering body weight in the clinical practice.

Calvillo M. Zenteno E. Heat shock proteins Hsps are expressed in response to several stress forms. Since the protein synthesis is increased, there is interest to investigate the Hsps role in pathology of Alzheimer disease AD.

It is known that Hsps interact directly with betasome one Hsps has been attributed lectinic activity i. The images were acquired with software IM of Leica microscopy.

The results show that inmunoreactivity levels in HsPs are increasing to respect to time of incubation when compared to control gruop.

It is known that C6 cells express high activity of synthesis and secretion of glycosaminoglycans. Proliferative and adhesive properties of the C6 are dependent on the expression of surface glycoproteins.

It was concluded that the stress modifies Hsps inmunoreactivity and sites whose recognized lectins are modified.

Biochemical determinations will be made to learn about the relationship between these proteins in vitro study. These protective mechanisms have evolved over many years and have provided interesting chemicals that can be learned and incorporate in cosmeceuticals products.

Antioxidants are compounds that can eliminate ROS and protect the body from free radicals. It has aroused great interest in free radicals and its relation to cell aging.

This increased oxidative stress at the cellular level resulting in pathophysiological processes such as cancer, cardiovascular disease, neurodegenerative Alzheimer, Parkinson and cataracts.

Therefore, it is vitally important to find molecules that are able to minimize or prevent damage caused by free radicals.

To determine the antioxidant capacity of tlanchalagua Erythraea tetramera Schiede Plant extracts was obtained by reflux with different solvents for 6 hrs, then concentrated under reduced pressure yielding about 10 ml.

Different concentrations were prepared extracts and tested for antioxidant activity with ABTS 2. We evaluated the ability to capture free radicals by the ABTS assay of each extract.

There is a higher antioxidant capacity in the ethanol extract Phytochemical screening of methanolic extract showed flavonoids principally.

Conclusions: Ethanol extract was the most powerful, with Neonatal administration of monosodium glutamate MSG to mice causes neurotoxicity of the Central Nervous System CNS resulting in endocrine, metabolic and behavioral abnormalities.

On the other hand the amphetamine is a potent stimulant drug on CNS because it induced catecholamine released.

The control group was vehicle-treated only saline injections. The decreased susceptibility to the stimulant effects of amphetamine may occur as a consequence of changes in neural excitability, down regulation of dopamine-receptors, synthesis inhibition of catecholamines, or might be related to pharmacokinetics modifications, induced by neonatal treatment with MSG.

Homoeostasis is a dynamic equilibrium process adjustable to the age of organisms. When the cardiovascular system is disrupted, this is mismatched.

Which could be partially or totally attenuated, depending on age and life style. It is proposed that exercise could reduce cardiovascular risk.

The aim of the present work was to study the effect of treadmill training on systolic pressure SP , heart rate HR and ventricular hypertrophy VH in young and old male mice with heart injury induced by isoproterenol ISO.

ISO was administered 24h after last exercise session. SP and HR were measured weekly by the tail-cuff method. Young sedentary showed higher variation ranges on SP ISO treatment decreased SP Old sedentary and exercised showed no significant differences on the variation ranges on SP nor HR.

ISO decreased SP Moreover, this suggest that arterial pressure stabilization by exercise could protect from adverse effects of a heart injury independently of the age.

While the hypertrophy caused by heart injury could be accentuated in exercised young and attenuated in exercised old organisms.

The effects of training and heart injury on cardiovascular system are age differentially adjusted. Background: Psychiatric diseases have become a public health problem owing to their increased prevalence.

An option for their treatment is psychoactive medications, which are associated with multiple adverse effects.

The purpose of this study was to determine the pharmacoepidemiology of psychoactive medication and the prevalence of psychiatric disease in adult patients seen at the Psychiatry Department at Durango General Hospital.

Methods: Clinical histories of the patients were reviewed for patients over 18 years of age that were seen at the outpatient clinic of the Psychiatry Department at Durango General Hospital that required psychoactive medication.

The study was conducted between January and February Results: The most commonly diagnosed conditions were the neurotic disorders, stress related disorders, and somatization disorders Seventy six percent of patients received more than one medication for their treatment.

The most commonly prescribed medications were the selective serotonin reuptake inhibitors, with Fluoxetine being the most prescribed medication Anxiolytics were the second most prescribed group, with Clonazepam being the most prescribed medication within this group Conclusions: Contrasting with the clinical practice guidelines, in which single drug therapy is recommended for most of the psychiatric diseases, only The age group with most prescriptions was between 30 and 59 years of age.

Torres , V. Uncontrolled high blood pressure increases the risk of heart disease, stroke, and kidney disease; it can also unnoticeably damage the heart, vessels, brain, and kidneys if not treated.

Some medicaments can control it. Diuretics, beta-blockers, ACE inhibitors and calcium channel blockers. But they have side effects.

In the laboratory of Dr. Two of these compounds one with morpholinic structure and the other with tiomorpholinic structure were used on glucose uptake of cardiomyocytes from hypertensive rats to characterize its heart protection properties.

Sodium, a major component of salt, can raise blood pressure by causing the body to retain fluid, which leads to a greater burden on the heart.

Increasing glucose uptake is a way of protecting the heart from hypoxic events and it is promoted by the glucose transporters Gluts. We raised the blood pressure in these animals by administrating a high salt diet and observe that hypertension does not permit the metabolic switch that would protect the cardiac cells during hypoxia.

These compounds have successfully lowered the blood pressure and improved the metabolic state of cardiomyocytes from hypertensive animals as well as regulating the function of the glucose transporters.

Epilepsy is one of the most common neurological disorders. Oxidative stress due to generation of mitochondrial ROS is strongly implicated in seizures in the disorder.

It has been demonstrated that TPM modulate the antioxidant enzyme system and has features that make it attractive as a potential neuroprotective agent.

In this work, We explored, for the first time, the in vitro ROS scavenger activity of this drug. These results indicate that TPM possesses antioxidant in vitro potential.

The epilepsy is an alteration characterized by excessive electric activity of the brain. The study of this syndrome has derived in diverse experimental models.

One of these is the penicillin G intracerebral administration, in which has not yet determined whether benzodiazepine mu-opioid and muscarinic receptors are modified.

Aim: To evaluate the in vitro levels of union of the benzodiazepine, mu-opioid and muscarinic receptors in rat brain areas, during the interictal period after the repetitive administration of penicillin G into amygdala nucleus.

The electrographic recordings were realized before and after injection. The animals were sacrificed 24 h after last administration and the brains were processed with in vitro autoradiography studies and benzodiacepine, mu-opioid and muscarinic receptors were evaluated in different brain areas.

Results: The epileptic focus basolateral amigdalae nucleus was confirmed through an electrographic recording and was associated with behavioural changes.

However, the results in other brain areas are different. Conclusion: The benzodiazepine, mu-opioid and muscarinic receptors are involved in the seizures induced by intraamygdaline administration of penicillin G in rat.

Human temporal lobe epilepsy is a chronic neurological disease. The study of this pathology has derived in diverse experimental models, between them, the seizures induced by intraamygdaline administration of penicillin G.

However, the basic neurochemical mechanisms those underlying these convulsions are unknown. For this reason, we evaluated the in vivo extracellular levels of alanine, aspartate, glycine, glutamine, glutamate and taurine in the amygdalae epileptic focus, after the intracerebral repetitive administration of penicillin G.

The electrographic recordings of the ipsilateral and contralateral amygdalae were realized before and after injection. In the 7th day last day of administration extracellular levels of neurotransmitters were evaluated in the epileptic focus through microdialysis studies.

Results: The epileptic focus basolateral amigdalae nucleus was confirmed through an electrographic recording. Aspartate had no change. Conclusion: Our results suggesting that the excitatory and inhibitory neurotransmitters are released during the seizures induced by intraamygdaline administration of penicillin G similarly to interictal changes that are observed in the human epileptic focus.

Its importance lies not only hyperglycemia, but in its consequences, increasing the risk of death from heart disease, cerebrovascular disease and renal failure, among others.

Since in type II diabetes has shown the presence of oxidative stress, is essential to study its relationship to some indicator that constitutes the most representative measurement of blood glucose: glycated hemoglobin.

Besides this, research on the abatement of oxidative stress represents a new fitomedication alternative adjunct in the management of DM.

We measured fasting glucose, Hb-A1 and oxidative stress markers among others, in the absence and presence of R. Related to this, lipoperoxidation increased significantly, which was prevented when the animals received the dose of extract of R.

This effect showed a modest decline in blood pressure and some metabolic disorders. The use of antioxidants as an alternative therapy for diabetes mellitus appears to be promising.

The mixture obtained contains importance as an agonist: therabaine, oripavine, erysodine whose concentration values are estimated in abundance by the chromatogram obtained.

The results shows that the seed is the part which contains a higher concentration of alkaloids followed by the corolla, and finally by the cup.

The more efficient extractions were obtained in the acidic compounds, which could be used as precursors of more potent substances to treat pain, like morphine, by other simplified routes.

The LD50 obtained is 3. The symptoms presented in the study group were paralysis of tail, hind limp prostration, convulsions, spasms and respiratory depression with hypothermia.

At concentration of Castillo-Henkel C. The aim of this paper is to analyze the changes of cyclooxygenase involvement in the contractile response to phenylephrine in the thoracic and abdominal aorta of prepubertal young and old rats.

During development there are changes in the activity of some enzymatic pathways, so particular in this work we analyze the change in the involvement of cyclooxygenase in the contractile effect of phenylephrine with age.

Cyclooxygenase is significantly involved in the release of prostanoids that regulate the effect of various agonists as in the case of phenylephrine, but not known that how this enzyme is involved during the development of the rat cardiovascular level.

In this experimental model we used male rats of 6, 16 weeks and 1 year of age. Then we proceeded to make concentration response curves to phenylephrine to M in the presence and absence of indomethacin COX antagonist.

Its has been shown in important way, that the relation between endothelia dysfunction and cardiovascular disease, however it has not related with vascular dysfunction associated to limb girdle muscular dystrophy and cardiopathy, in order to analyze the participation of the nitric oxide and prostacyclin on this experimental model of delta-sarcoglican null mice.

Finally we proceeded to make curves concentration response to -9 -5 -9 -6 acetilcoline 10 - 10 and sodium nitroprusiate 10 - We obtain differences in the coronary pressure and aorta relaxation with acethilcoline between Knock-out and wild type mice, in other hand the relaxation to sodium nitroprusiate not show differences in the thoracic aorta between knock-out and wild type mice, unlike we have differences in the coronary pressure with sodium nitropusiate.

Our results suggest changes in the relaxation independent of endothelium in artery coronary but not in thoracic aorta, although both vessels show differences in the relaxation dependent of endothelium.

Hypertension targets small and large arteries as well as organs, such as heart and kidney. Interestingly, captopril increased Ang II-induced pressor response in isolated kidney of SHR rats after 2 weeks treatment; whereas it diminished basal perfusion pressure in SHR rats 14 weeks after, and drastically reduced Ang II-elicited pressor response.

Data indicate that captopril influences both expression and function of AT 1 receptors in kidney of pre-hypertensive and adult SHR rats, probably avoiding AT1 receptor expression by blockade of angiotensin II synthesis.

The aim of the present study was to determine the prescribing practice for clozapine as well as the plasma levels of clozapine and its main metabolite norclozapine in Mexican patients.

A prospective study was performed in 69 in and out psychotic patients taking clozapine. Blood samples were taken at steady state.

Plasma concentrations of clozapine and norclozapine were determined by HPLC. Demographic variables as weight, gender and age were not significant.

Plasma levels showed a large interindividual variability and were significant higher in patients under treatment with fluoxetine.

Mean plasma levels were When data were compared with those reported in other populations, it was found that although the dose was lower than that reported in Caucasians, the plasma levels were similar.

As a result, the predictive models for the estimation of clozapine concentration in Caucasians were not appropriate for its application in Mexican patients.

Further studies are required to expand the observations. There is clearly a need for more and better AEDs. The compound DLhydroxyphenylpentanamide DL-HEPP protects mice and rats against seizures induced by pentylenetetrazol PTZ , maximal electroshock MES , bicuculline, 4-aminopyridine, thiosemicarbazide, hippocampal kindling, gammaaminobutyric acid withdrawal syndrome and against the focal spike activity in the genetic absence epilepsy rats of the Strasbourg model.

In this work we report the resolution of the compound DL-HEPP and the anticonvulsant evaluation and neurotoxicity of its enantiomers.

In the rotarod ataxia test the neurotoxicity of DL-HEPP and its enantiomers was similar, but a variation in time between the enantiomers was found with the anticonvulsant activity in the PTZ model.

Phenobarbital was used as the reference drug. Epilepsy is one of the most common neurological disorders affecting around 0.

In Mexico the incidence is calculated around 15 persons per The results obtained confirmed the structure proposed.

The effective doses 50 obtained via i. In conclusion the inclusion of the trifluoromethyl group in the phenyl ring of DL-HEPB increased its antoconvulsant activity.

Midazolam is a short-acting benzodiazepine commonly used to induce anaesthesia or sedation in children. In Mexico, a commercial oral pediatric formulation of midazolam is not available yet and it is usually administered by mixing the parenteral solution with apple juice; this formulation has the disadvantage of having a bitter and unpleasant flavour.

In the present work, we developed and validated an HPLC method to quantify midazolam in a new white chocolate formulation.

The stability of this formulation was evaluated at different storage conditions and a preliminary assay of relative bioavailability was carried out in healthy -1 volunteers.

The relative bioavailability assay suggests that our preparation of midazolam in white chocolate reaches plasma levels and induces pharmacologic effects compared to those induced by the apple juice formulation.

This new white chocolate formulation masks the unpleasing flavour and has a more attractive presentation to the paediatric patient, which may be useful for children sedation and to ease its management by health carers.

Thalamic Reticular nucleus TRn has been involved in regulation of afferents to thalamiccortical loops participating in attention process.

TRn receives dopaminergic innervation, shared with striatum and globus pallidus, from substantia nigra compacta Anaya-Martinez et al, , and we have reported an anxiolytic effect induced by bilateral 6-OHDA lesion of TRn Picazo et al, This effect was assigned to alterations on detection of stimuli need it to elicit anxiety responses.

If this is true other behavioral aspects interrelated to anxiety as memory process could be affected by this lesion. Because the inter-hemis-pheric connection of both TRn, we probed unilateral lesion by local administration of 6-OHDA in a group of male Wistar rats.

Right lesion was confirmed by ipsilateral turning behavior induced by systemic apomorphine 8 days post-surgery and by microscopic observation of brain slices.

Hemi-lesioned rats compared with sham group had a lesser percent time in open arms in EPM, in NOR showed a minor ratio of time exploring the novel object, in RAM the acquisition was slower and in the retention phase they had more reference errors and in MWM they showed a larger latency to find the platform in the first assays of acquisition phase.

So, unilateral 6-OHDA lesion replied the anxiolytic effect of bilateral lesion of TRn and besides unrevealed cognitive deficiencies in memory consolidation.

These models were energetically optimized with NAMD 2. Then, we analyzed the ligand recognition by docking methods with Autodock4 program.

Cinvestav, Unidad Monterrey, N. Mammalian sperm, in his transit through the female genital tract, acquire the ability to fertilize the egg in a process called capacitation.

During this event, the intracellular levels of cAMP and cGMP increase, suggesting that cyclic nucleotide-gated CNG channels, which have been identified in mammalian sperm, play a functional role in their physiology.

Here we report an electrophysiological characterization of the effect of cyclic nucleotides on capacitated and non-capacitated mouse sperm.

CP O With the purpose to find out a possible profile of successful students at Medical School at Universidad Nacional Autonoma de Mexico campus CU , we studied some academic and personal variables and its short-term and longterm influence over knowledge domain at the end of medical school.

Variables studied: 1 Diagnostic test of high school knowledge at beginning of Medical School, high school attended before Medical School, 2 Basic knowledge test when starting pharmacology nd course, 3 Student achievement in Pharmacology, 4 Assigned group in 2.

The convenience sample was composed by 68 students: 34 men and 34 women, selected from five groups. Results showed: 1.

Significative differences in the diagnostic test at beginning of Medical School in regard to attended high school, 2.

Significative differences in scholar achievement of Pharmacology depending on group where students belong by registration groups are chosen by students depending on their average grades.

Significative differences in scholar achievement of Pharmacology depending on the opinion of students about studying materials.

Correlation between Pharmacology grades and grades in medical graduate examination at expected time of graduation terminal efficiency.

Other Learning and self-regulation strategies that were analysed, did not show differences on achievement results in Pharmacology, nor on medical graduate examination.

Carpio y Plan de Ayala. We used a prodrug of N-butyl oxamate, which was the ethyl ester of N-butyl oxamate.

We performed assays on motility, viability and acrosome reaction in mice spermatozoa in absence and presence of different concentrations of the ethyl ester of the N-butyl oxamate.

We found that this prodrug inhibited all the parameters before mentioned, and in the screening of the results, we found a concentration-dependent effect.

We determined the LD50 that it was of We assayed the effect of the inhibitor in vivo and we found that this inhibitor diminished the motility of mice spermatozoa, without affecting the activity of the LDH-C4.

Finally, because all our results, we can suggest the ethyl ester of the N-butyl oxamate can be a target for future studies as a possible male specific contraceptive.

Xochimilco UAMX. Glutamate Glu , most abundant excitatory neurotransmitter in central nervous system, participates in natural feeding, thirst, sex and pathologic addiction and chronic drug abuse behaviors by means of ionotropic NMDA, AMPA and Kainate types and metabotropic glutamatergic mGluRs receptors.

Glu has been associated with neuroplastic changes, as a consecuence of abuse and relapse to consumption of psychostimulants cocaine, amphetamine.

Chronic drug abuse, produces increasing alterations of dopaminergic and glutamatergic neurotransmission.

Pathologic behaviors have been most frequently investigated, by its impact in the health. However, there is not the same interest to study the natural behaviors.

So, we decided analized the role of Glu in a natural motivated behavior. To this purpose, we evaluated the effect of the monosodium salt of glutamate, compared to ketamine hydrochloride non competitive glutamatergic NMDA receptor antagonist , in a model of natural motivated behavior, using a female mice, as a incentive stimuli.

Time exhausted to find the incentive sitmuli, was measured when the animals were individually put into a radial maze six arms.

This procedure was similar for both treatments, in all of the three experimental tests, and a previous first test, as an indicator of average time with no drug , was included.

Latency was varied at 5, 15 and 30 minutes, each other test, respectively. Sede Sur. Sexual exhaustion is a condition of prolonged sexual behavior inhibition resulting from ad libitum copulation of a male with a single receptive female.

Gutamatergic neurotransmission has a facilitative role in sexual behavior expression of sexually experienced male rats. Sexually exhausted male rats differ in several behavioral aspects when compared to sexually experienced, non exhausted animals.

Thus, the sexual behavior facilitative effect of electrically stimulating the medial preoptic area, ventral tegmental area VTA and nucleus accumbens is lost in sexually satiated rats.

Additionally, they show a generalized hypersensitivity to drugs when compared to non exhausted males. These evidences suggest the occurrence of neuroplastic changes resulting from repeated brain activation during ad libitum copulation.

We hypothesized that glutamatergic receptor antagonists could reverse the sexual inhibition of satiated animals. Systemic administration of all glutamatergic antagonists facilitated sexual behavior expression in satiated rats, reversing sexual exhaustion at specific dose levels.

Thus, glutamate seems to play opposite roles in the regulation of sexual behavior expression of sexually satiated and sexually experienced male rats.

The osteoporosis keeps a relatively high prevalence in direct relationship with the age. Risk factors that influence the osteoporosis are smoking, obesity, sedentary and oxidative stress.

Recent studies have shown that both the oxidative stress plays an important role in the bone loss, and also, that the antiosteoporotic drugs can decrease the oxidative stress levels in postmenopausal patients with osteoporosis.

The objective of this study was to determine the concentrations of nitric oxide as a marker of oxidative stress and its relationship with bone mineral density in postmenopausal women.

Corona-Ortega T. Recently we had reported the construction of a nanocarrier structure that expresses non-covalently bound IL-2 on its external surface that renders the particle susceptible to be attached to IL-2R-bearing cells.

Our hypothesis for antitumor activity resides in the fact that the IL-2 bearing nanocarrier could promote close proximity of lymphocytes and tumor cells by the fact that both posses the IL2R.

Then if the close proximity of tumor cells with lymphocytes mediated by our nanoparticles could favor the recognition of a putative tumor antigen by the IL-2 activated lymphocytes a cytolytic activity could be induced.

Our results demonstrated that in fact these nanoparticles did bind to cervical cancer cells that express the IL-2R, making them in turn IL-2 presenters that attracted blood lymphocytes and induced tumor cell lysis.

Thus we can speculate that the IL-2 bearing nanocarrier attached to the IL-2R on the tumor cell and then before it was endocytized attracted lymphocytes, also through their IL-2R, acting as a bridge between tumor cells and lymphocytes that favored the recognition of tumor antigens and thus induced the antitumor response obtained.

Based on these finding, we investigated the identity of the receptor subtype that mediates renal vasoconstriction in isolated perfused kidneys of diabetic rats.

Methods: Renal vascular tone was evaluated in the isolated perfused kidneys of control and diabetic rats. Results: A bolus injection of S1P produced dosedependent renal vasoconstriction in the isolated perfused kidneys of control and diabetic rats, but the vasoconstriction was greater in the kidneys of diabetic rats compared with the kidneys of control rats These results demonstrate that, in the isolated perfused kidneys of diabetic rats, the S1P induced renal vasoconstriction through the S1P2 receptor.

In addition, we observed increased expression of the S1P 2 receptor at the mRNA and protein levels in the kidneys of diabetic rats compared with those of controls Conclusion: In the present study, we have shown that S1P induces renal vasoconstriction through the S1P2 receptor and that antagonists of this receptor may have potential as drugs to control diabetes-induced vascular complications.

However, there is very few information about the expression of this receptor in models of chronic kidney disease and its expression patterns when drugs for hypertension are used..

The drugs were oral administrated and animals were followed-up for 60 days. Protein in h urine was measured at weeks 2, 4, 6 and 8 after surgery.

At day 60 systolic blood pressure was assessed by aorta cannulation, rats were sacrificed to obtain: plasma for the determination of Ang II and Ang , and renal tissue for the evaluation of expression levels by quantitative PCR.

Blood pressure was significantly increased in the NFX group compared with the other groups Levels of Ang II 1.

In this condition are induced important changes on electrocardiogram EKG , blood pressure BP , another phenomenon immediately after AMI, is the reperfusion, which generates oxidative stress, In this work we studied, comparatively in dog and rabbit, the changes occurred during experimental AMI-reperfusion and the effect of Rosmarinus officinalis extract in order to know if the antioxidative action can modify the alterations postIAM.

AMI was induced in dogs. At open chest, we proceeded to occlude the left coronary artery; ischemia was maintained for 90 min and after released artery occlusion, reperfusion was min more.

New Zealand rabbits, were exposed to the same procedure, but, both coronary occlusion and reperfusion were kept by 35 min; EKG and BP were obtained.

Five dogs died by ventricular fibrillation. During reperfusion was also present A-V dissociation and ventricular tachycardia.

Changes occurred in ST segment and drop in systolic and diastolic pressures during reperfusion. In experimental AMI, I. And the resolution could be getting this new job.

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Get rid of your headache and let us help you improve your grades. Health Promotion in Nursing Practice A BitTorrent file distribution consists of these entities: There are ideally many end users for a single file.

Start running a tracker or, more likely, have one running already. Start running an ordinary web server, such as apache, or have one already.

Associate the extension. Generate a metainfo. Put the metainfo file on the web server. Link to the metainfo.

Start a downloader which already has the complete file the 'origin'. Install BitTorrent or have done so already. Surf the web. Click on a link to a.

Select where to save the file locally, or select a partial download to resume. Wait for download to complete. Tell downloader to exit it keeps uploading until this happens.

Metainfo files also known as. All strings in a. The name key maps to a UTF-8 encoded string which is the suggested name to save the file or directory as.

It is purely advisory. For the purposes of transfer, files are split into fixed-size pieces which are all the same length except for possibly the last one which may be truncated.

It is to be subdivided into strings of length 20, each of which is the SHA1 hash of the piece at the corresponding index. There is also a key length or a key files , but not both or neither.

If length is present then the download represents a single file, otherwise it represents a set of files which go in a directory structure.

In the single file case, length maps to the length of the file in bytes. For the purposes of the other keys, the multi-file case is treated as only having a single file by concatenating the files in the order they appear in the files list.

The files list is the value files maps to, and is a list of dictionaries containing the following keys: length - The length of the file, in bytes.

In the single file case, the name key is the name of a file, in the muliple file case, it's the name of a directory.

Tracker GET requests have the following keys: The 20 byte sha1 hash of the bencoded form of the info value from the metainfo file.

This value will almost certainly have to be escaped. Note that this is a substring of the metainfo file.

The info-hash must be the hash of the encoded form as found in the. Conversely that means clients must either reject invalid metainfo files or extract the substring directly.

They must not perform a decode-encode roundtrip on invalid data. Each downloader generates its own id at random at the start of a new download.

This value will also almost certainly have to be escaped. Generally used for the origin if it's on the same machine as the tracker.

Common behavior is for a downloader to try to listen on port and if that port is taken try , then , etc. Note that this can't be computed from downloaded and the file length since it might be a resume, and there's a chance that some of the downloaded data failed an integrity check and had to be re-downloaded.

If not present, this is one of the announcements done at regular intervals. An announcement using started is sent when a download first begins, and one using completed is sent when the download is complete.

No completed is sent if the file was complete when started. Downloaders send an announcement using stopped when they cease downloading.

Tracker responses are bencoded dictionaries. If a tracker response has a key failure reason , then that maps to a human readable string which explains why the query failed, and no other keys are required.

Otherwise, it must have two keys: interval , which maps to the number of seconds the downloader should wait between regular rerequests, and peers.

Note that downloaders may rerequest on nonscheduled times if an event happens or they need more peers.

More commonly is that trackers return a compact representation of the peer list, see BEP If you want to make any extensions to metainfo files or tracker queries, please coordinate with Bram Cohen to make sure that all extensions are done compatibly.

It is common to announce over a UDP tracker protocol as well. Peer connections are symmetrical. Messages sent in both directions look the same, and data can flow in either direction.

The peer protocol refers to pieces of the file by index as described in the metainfo file, starting at zero. When a peer finishes downloading a piece and checks that the hash matches, it announces that it has that piece to all of its peers.

Connections contain two bits of state on either end: choked or not, and interested or not. Choking is a notification that no data will be sent until unchoking happens.

The reasoning and common techniques behind choking are explained later in this document. Data transfer takes place whenever one side is interested and the other side is not choking.

Interest state must be kept up to date at all times - whenever a downloader doesn't have something they currently would ask a peer for in unchoked, they must express lack of interest, despite being choked.

Implementing this properly is tricky, but makes it possible for downloaders to know which peers will start downloading immediately if unchoked.

Connections start out choked and not interested. When data is being transferred, downloaders should keep several piece requests queued up at once in order to get good TCP performance this is called 'pipelining'.

On the other side, requests which can't be written out to the TCP buffer immediately should be queued up in memory rather than kept in an application-level network buffer, so they can all be thrown out when a choke happens.

The peer wire protocol consists of a handshake followed by a never-ending stream of length-prefixed messages.

The handshake starts with character ninteen decimal followed by the string 'BitTorrent protocol'. The leading character is a length prefix, put there in the hope that other new protocols may do the same and thus be trivially distinguishable from each other.

All later integers sent in the protocol are encoded as four bytes big-endian. After the fixed headers come eight reserved bytes, which are all zero in all current implementations.

If you wish to extend the protocol using these bytes, please coordinate with Bram Cohen to make sure all extensions are done compatibly.

Next comes the 20 byte sha1 hash of the bencoded form of the info value from the metainfo file. If both sides don't send the same value, they sever the connection.

The one possible exception is if a downloader wants to do multiple downloads over a single port, they may wait for incoming connections to give a download hash first, and respond with the same one if it's in their list.

After the download hash comes the byte peer id which is reported in tracker requests and contained in peer lists in tracker responses.

If the receiving side's peer id doesn't match the one the initiating side expects, it severs the connection.

That's it for handshaking, next comes an alternating stream of length prefixes and messages. Messages of length zero are keepalives, and ignored.

Keepalives are generally sent once every two minutes, but note that timeouts can be done much more quickly when data is expected.

All non-keepalive messages start with a single byte which gives their type. The possible values are: 'choke', 'unchoke', 'interested', and 'not interested' have no payload.

Its payload is a bitfield with each index that downloader has sent set to one and the rest set to zero. Downloaders which don't have anything yet may skip the 'bitfield' message.

The first byte of the bitfield corresponds to indices 0 - 7 from high bit to low bit, respectively. The next one , etc. Spare bits at the end are set to zero.

The 'have' message's payload is a single number, the index which that downloader just completed and checked the hash of.

The last two are byte offsets. Length is generally a power of two unless it gets truncated by the end of the file. They are generally only sent towards the end of a download, during what's called 'endgame mode'.

When a download is almost complete, there's a tendency for the last few pieces to all be downloaded off a single hosed modem line, taking a very long time.

To make sure the last few pieces come in quickly, once requests for all pieces a given downloader doesn't have yet are currently pending, it sends requests for everything to everyone it's downloading from.

To keep this from becoming horribly inefficient, it sends cancels to everyone else every time a piece arrives.

Note that they are correlated with request messages implicitly. Downloaders generally download pieces in random order, which does a reasonably good job of keeping them from having a strict subset or superset of the pieces of any of their peers.

Choking is done for several reasons. TCP congestion control behaves very poorly when sending over many connections at once.

Also, choking lets each peer use a tit-for-tat-ish algorithm to ensure that they get a consistent download rate. The choking algorithm described below is the currently deployed one.

It is very important that all new algorithms work well both in a network consisting entirely of themselves and in a network consisting mostly of this one.

There are several criteria a good choking algorithm should meet. It should cap the number of simultaneous uploads for good TCP performance.

It should avoid choking and unchoking quickly, known as 'fibrillation'. It should reciprocate to peers who let it download.

Finally, it should try out unused connections once in a while to find out if they might be better than the currently used ones, known as optimistic unchoking.

The currently deployed choking algorithm avoids fibrillation by only changing who's choked once every ten seconds. It does reciprocation and number of uploads capping by unchoking the four peers which it has the best download rates from and are interested.

Peers which have a better upload rate but aren't interested get unchoked and if they become interested the worst uploader gets choked. If a downloader has a complete file, it uses its upload rate rather than its download rate to decide who to unchoke.

For optimistic unchoking, at any one time there is a single peer which is unchoked regardless of its upload rate if interested, it counts as one of the four allowed downloaders.

Which peer is optimistically unchoked rotates every 30 seconds. To give them a decent chance of getting a complete piece to upload, new connections are three times as likely to start as the current optimistic unchoke as anywhere else in the rotation.

The BitTorrent Economics Paper outlines some request and choking algorithms clients should implement for optimal performance When developing a new implementation the Wireshark protocol analyzer and its dissectors for bittorrent can be useful to debug and compare with existing ones.

This document has been placed in the public domain. Singkat, Padat, dan Jelas Ingat bahwa perusahaan membutuhkan resume untuk mempercepat waktu mereka melakukan seleksi sebelum interview.

Oleh karena itu, waktu untuk melihat tiap resume juga sangat singkat menit sehingga resume yang kita buat harus benar benar padat dan jelas.

Untuk orang yang sudah mempunyai pengalaman kerja cukup lama, halaman masih bisa ditoleransi tetapi tetap usahakan dalam 1 halaman kecuali anda benar2 memiliki hal khusus yang perlu ditulis sebanyak itu.

Context Action Result CAR framework Ketika saya melihat resume dari beberapa orang dalam menulis pengalaman kerja, biasanya mereka hanya menulis judul dari pekerjaannya dan waktunya.

Contoh: - Sales Representative PT. Grosir Baju Indonesia - Dengan teknik penulisan seperti itu, apa yang bisa dilihat oleh perusahaan.

Perusahaan hanya tahu bahwa kita punya pengalaman menjadi sales representative selama 4 tahun dan sales supervisor selama 2 tahun di PT.

Grosir Baju Indonesia. Tetapi Perusahaan tidak akan pernah bisa melihat nilai lebih yang anda tawarkan.

Ketika mereka melihat resume dari kandidat lain mereka akan melihat hal yang sama. Bandingkan jika anda menulis seperti ini.

Contoh Lain pengalaman sebagai programmer : - Membuat program akuntasi dengan cepat. Telp, E-mail. Untuk Tempat tanggal lahir, biasanya tidak perlu dimasukkan karena orang akan sudah bisa mengetahui dari waktu anda menempuh pendidikan terakhir.

Tidak perlu mencantumkan daftar pendidikan mulai SD. Orang hanya tertarik untuk mengetahui pendidikan terakhir anda. Untuk mengetahui contoh aplikasi teknik cara membuat resume bisa anda lihat di.

Artikelnya sangat bermanfaat, terima kasih Admin untuk sharingnya. Terima kasih infonya bro, sangat membatu saya.. Terimakasih untuk informasinya.

Setidaknya dapat membantu dalam menambah wawasan kita. Be Careful. Urus Pendirian PT. Urus Pendirian CV.

Urus Ijin Prinsip dan perubahan. Urus Rekomendasi Departemen Perindustrian. Urus Merk Dagang. Urus Ijin ISO Urus Pernikahan di Luar Negeri Beda Agama Dan masih banyak lagi perijinan lainnya untuk informasi lebih lanjut silahkan hubungi kami: atau.

How long did you walk your child to the door for school? Context : Macbeth is talking to the earth, in a soliloquy. Significance : There are several possible meanings to this quote.

If Macbeth is saying that sound will spoil the mood, then that is an example of metatheatre, which in a way, takes away from the gruesome details of the murder, as it somewhat breaks the forth wall and remind the listeners that Macbeth is only a character in a play.

This quote contains apostrophe, as Macbeth is talking to an inanimate object, and personification. Context : This quote is said by Macbeth to Lady Macbeth.

Macbeth had just killed Duncan, and he and Lady Macbeth are discussing what he had done. Macbeth is horrified and imagines voices that speak of his evildoings.

Macbeth will not sleep anymore. Later, Macbeth refers to himself using his three names, which could symbolize the three stages of his prophesy and his development.

Therefore, Glamis could symbolize his past self, which he was before he killed Duncan, Cawdor could symbolize his current self, which is who killed Duncan, and Macbeth could refer to his future self.

This follows the motif of three, as there were three witches and Hecate was commonly portrayed with three faces. He feels very guilty, worried, and paranoid, so much as that he believes he will never be able to sleep again.

His sleep will disappear along with his innocence, as sleep is depicted as innocent and good. The witches punish people with lack of sleep, such as when they punished the sailor whose wife was mean with a lack of sleep.

This quote contains many metaphors. Context : This quote is said by Ross to an old man. They exchanging accounts of recent unnatural happenings.

It is the morning after Macbeth killed Duncan. Meaning : According to the clock, it is day, but darkness blocks the sun.

Is it dark because night has become more powerful than day, or because day is hiding its face in shame?

People at this time believed that social standing was determined by God, so trying to usurp someone to put yourself in their place goes against the natural order of things.

Kings were believed to also have been chosen by divine powers, so killing and usurping Duncan was especially heinous.

The falcon could be representing King Duncan, while the owl, a bird often attributed to death, could represent witchcraft; therefore, this could be saying that witchcraft has killed Duncan.

Also, night, which can represent evil, is taking over day, which is good and supposed to be predominate. This quote contains personification and metaphors.

Context : Macbeth is talking to himself, in a soliloquy. I have ruined my peace for their benefit and given my soul to the devil to make them, the sons on Banquo, kings.

Instead of letting that happen, let fate come to the arena and fight me to the death. Macbeth, who committed evil deeds, will be punished, while Banquo, who has been good and loyal to the king, will be rewarded.

This quote also contains personification and metaphors. Context : Macbeth is speaking to Lady Macbeth. Meaning : We have hurt the snake, but have not killed it.

It is better to be with the dead, whom we have killed and put to rest in order to secure our peace, than to lie with tortured minds in a frenzy of sleeplessness.

He decides that he rather destroy the world than continue to live in fear, which indicates the reign of terror that Scotland will fall under.

Simply choose your favorite and get started. Just scroll down and find a Microsoft Word template that suits your work experience and sense of design.

Save time and effort — it does all of the writing and formatting for you. Click the button below and get started!

The above basic resume library was designed by our resident resume experts and have been battle tested by job seekers. As this set performed the best, we included them in our resume builder software— and now we are offering them to you for free to download in Microsoft Word format.

Each professional template comes in five colors. Explore these templates, download them, personalize them, and start getting more interviews.

Resume Template Library 2: Advanced Layouts. Professional Brick Red. Timeless Dark Blue. Elegant 2. Modern Brick Red. Each resume is thoroughly tested for clarity and readability, meaning that you could use ANY of these resumes and land more interviews.

So have fun, and pick one that suits your sense of design. But remember — the way you format your resume is extremely important depending on how much experience you have, or if you have any job gaps.

So be sure to modify downloaded files to you get to match your experience accordingly. Template Library 3: Professional Profile Layouts.

Washington Brick Red. Murray Dark Blue. Trump Brick Red. Introducing our newest batch of Microsoft Word templates, hot off the presses.

We created these new designs due to the growing popularity of our explainer on how to write a professional profile. People interested in a layout featuring a PP introduction skyrocketed, so we toiled to create 8 brand new HR-approved documents for you to download for free.

Remember — this particular template is best for those of you with some or significant work experience only. Template Library 4: Creative Layouts.

Brooklyn Bridge Black. Taj Mahal Dark Blue. White House Brick Red. Empire State Gray. Mount Rushmore Dark Blue. Are you having trouble separating yourself from your competitors?

Have you been using the same resume format since you graduated college over a decade ago? Then it might be time to add some style to your resume!

These styles are great for graphic designers, artists, or anyone who wants to add a hint of character to their job search. Job Hopper Original.

Mid-Level Dark Blue. Career Changer Brick Red. Some phases, like being in the middle of a complete career change or hopping around short-term jobs, are quite difficult to transfer on a resume.

Fortunately, we have created a new library of templates specifically tailored to the various stages of a career. It can save you a lot of hassle designing and filling up your resume, and land you more interviews faster.

Not Sure Which Template to Choose? The answer is yes — if you want to. Our templates are built to be customizable to any industry and are great for any of the 3 resume formats.

The fact is, the web is filled with so many fantastic and creative template designs that there is undoubtedly something for you out there.

Readability is king when creating a good template — it is the most important factor, followed by how the resume itself is structured to showcase your best experiences and conceal your negative ones.

Creating your own is fine, too. Wrong again. Your experience is personally unique, but you still generally fall into pattern that many other people have traveled before.

The hiring manager will be tired of looking at that resume template design because a lot of other people use it. That hiring manager should be fired.

We hope that clears up any misconceptions you may have had. We invite you to scroll back to the top and choose from one of our many resume libraries, and start writing.

Should i include collegiate sports in my resume? And if so where? It depends how much professional experience you have. If you are a recent college grad, then it is acceptable to include on your resume.

Good luck on the job hunt! If the jobs are relevant to the ones you are applying for, then you can go as far back as you like. Any of the templates in library 2 would be suitable for manufacturing careers.

Best of luck! Multiple employers with jobs lasting two to three years each. The jobs have been similar, so the experience looks a bit repetitive.

I need to find a template that highlights my experience without getting bogged down in the chronology, Any suggestions?

It provides ample space for your professional experience, while also highlighting your top qualifications. How would I write that on my resume?

Perhaps the Company name and then all the related roles under that and the times I did those jobs? I was always the Executive Admin, but I did other jobs during that period.

Yes, your suggestion is correct. Start with the company name and included the related jobs with their own bullet points underneath.

Good luck! Ive never had a job so what should I use? Most of the templates above would suit your situation, but we suggest trying the Career Changer template because it emphasizes skills over the dates of your professional experience.

Good luck with grad school! Hope this helps! Good luck with the internship! Good Day Resume Genius. The skill I know is more on the medical.

What template should I use? Which is good for cabin crew applicant? I have no many work experience in service. So i want to highlight the other things.

Which template would you recommend for a career in education? Best of luck on the promotion! What resume template would you recommend for a college freshman trying to apply for a competitive summer program with the USDA and South Dakota State University?

Good luck with the summer program. Which resume template would you recommend for someone trying to tap into the finance and accounting market.

Looking for an entry-level position. Good luck with the job hunt. Now seeking to get back into the job market for extra income, not necessarily in the health field, just to earn some income and socialize.

What resume do you suggest? Good luck with your job search! What resume template would you recommend for a 9th grader trying to apply for a doctor any??

Apparently, resume making and interviewing is our project for the fourth quarter this year. Good luck on your project.

Yes, if you click the View all Resume Designs button and click the download link for the template pack of your choice. Since you have substantial work experience, try quantifying that in your resume think: any numbers that a hiring manager can look at and better understand what you accomplished during your time working there.

Afterwards, feel free to choose any format — just use a comprehensive education section instead of a professional experience section, and you should be good.

Good luck landing that internship! Get awesome job opportunities sent directly to your inbox. Think you can judge the quality of a resume within 6 seconds?

The answer may surprise you. Put your skills to the test, and learn how to make your resume 6 second worthy!

There are tons of errors throughout. See why. How to Modify and Maximize your Resume Template.

Need a resume template? Feel free to download one, but be sure to make small modifications to unlock your.

Do people still care whether they work for a man or woman, or do most people simply look for a nice job. Resume Builder Comparison Resume Genius vs.

LinkedIn Labs. What are the differences between the major online resume builders? Here's an in depth analysis of what.

Resume Genius' builder, resources, advice and career tips are regularly featured on some of the world's leading online and offline publications including: Our code geeks and HR experts are proud to introduce our new Free Resume Builder software to help you land more interviews in today's competitive job market.

The rich are the big gainers in America's new prosperity. Add this article to your reading list by clicking this button.

The gap between rich and poor is bigger than in any other advanced country, but most people are unconcerned. Whereas Europeans fret about the way the economic pie is divided, Americans want to join the rich, not soak them.

Eight out of ten, more than anywhere else, believe that though you may start poor, if you work hard, you can make pots of money.

It is a central part of the American Dream. Thanks to a jump in productivity growth after , America's economy has outpaced other rich countries' for a decade.

In the late s everybody shared in this boom. Though incomes were rising fastest at the top, all workers' wages far outpaced inflation.

But after something changed. The pace of productivity growth has been rising again, but now it seems to be lifting fewer boats.

If you take into account the value of employee benefits, such as health care, the contrast is a little less stark. But, whatever the measure, it seems clear that only the most skilled workers have seen their pay packets swell much in the current economic expansion.

The fruits of productivity gains have been skewed towards the highest earners, and towards companies, whose profits have reached record levels as a share of GDP.

Even in a country that tolerates inequality, political consequences follow when the rising tide raises too few boats.

The impact of stagnant wages has been dulled by rising house prices, but still most Americans are unhappy about the economy.

The White House professes to be untroubled. He is right, but his claim is misleading, since the median worker—the one in the middle of the income range—has done less well than the average, whose gains are pulled up by the big increases of those at the top.

Privately, some policymakers admit that the recent trends have them worried, and not just because of the congressional elections in November.

The statistics suggest that the economic boom may fade. Americans still head to the shops with gusto, but it is falling savings rates and rising debts made possible by high house prices , not real income growth, that keep their wallets open.

A bust of some kind could lead to widespread political disaffection. Eventually, the country's social fabric could stretch.

America is nowhere near Brazil yet see chart 1. Despite a quarter century during which incomes have drifted ever farther apart, the distribution of wealth has remained remarkably stable.

The richest Americans now earn as big a share of overall income as they did a century ago see chart 2 , but their share of overall wealth is much lower.

Indeed, it has barely budged in the few past decades. The elites in the early years of the 20th century were living off the income generated by their accumulated fortunes.

Today's rich, by and large, are earning their money. The rise of the working rich reinforces America's self-image as the land of opportunity.

But, by some measures, that image is an illusion. In America about half of the income disparities in one generation are reflected in the next.

In Canada and the Nordic countries that proportion is about a fifth. It is not clear whether this sclerosis is increasing: the evidence is mixed.

Many studies suggest that mobility between generations has stayed roughly the same in recent decades, and some suggest it is decreasing.

Even so, ordinary Americans seem to believe that theirs is still a land of opportunity. The proportion who think you can start poor and end up rich has risen 20 percentage points since That helps explain why voters who grumble about the economy have nonetheless failed to respond to class politics.

Americans tend to blame their woes not on rich compatriots but on poor foreigners. More than six out of ten are sceptical of free trade.

A new poll in Foreign Affairs suggests that almost nine out of ten worry about their jobs going offshore.

Congressmen reflect their concerns. Though the economy grows, many have become vociferous protectionists. Other rich countries are watching America's experience closely.

For many Europeans, America's brand of capitalism is already far too unequal. Such sceptics will be sure to make much of any sign that the broad middle-class reaps scant benefit from the current productivity boom, setting back the course of European reform even further.

The conventional tale is that the changes of the past few years are simply more steps along paths that began to diverge for rich and poor in the Reagan era.

During the s and s, the halcyon days for America's middle class, productivity boomed and its benefits were broadly shared.

The gap between the lowest and highest earners narrowed. After the oil shocks, productivity growth suddenly slowed.

A few years later, at the start of the s, the gap between rich and poor began to widen. The exact size of that gap depends on how you measure it.

Look at wages, the main source of income for most people, and you understate the importance of health care and other benefits.

Look at household income and you need to take into account that the typical household has fallen in size in recent decades, thanks to the growth in single-parent families.

Look at statistics on spending and you find that the gaps between top and bottom have widened less than for income. But every measure shows that, over the past quarter century, those at the top have done better than those in the middle, who in turn have outpaced those at the bottom.

The gains of productivity growth have become increasingly skewed. If all Americans were set on a ladder with ten rungs, the gap between the wages of those on the ninth rung and those on the first has risen by a third since Economists have long debated why America's income disparities suddenly widened after The consensus is that the main cause was technology, which increased the demand for skilled workers relative to their supply, with freer trade reinforcing the effect.

Some evidence suggests that institutional changes, particularly the weakening of unions, made the going harder for people at the bottom.

Whether these shifts were good or bad depends on your political persuasion. Those on the left lament the gaps, often forgetting that the greater income disparities have created bigger incentives to get an education, which has led to a better trained, more productive workforce.

In their haste to applaud or lament this tale, both sides of the debate tend to overlook some nuances. First, America's rising inequality has not, in fact, been continuous.

The gap between the bottom and the middle—whether in terms of skills, age, job experience or income—did widen sharply in the s.

But during the s, particularly towards the end of the decade, that gap stabilised and, by some measures, even narrowed. Real wages rose faster for the bottom quarter of workers than for those in the middle.

After most people lost ground, but, by many measures, those in the middle of the skills and education ladder have been hit relatively harder than those at the bottom.

People who had some college experience, but no degree, fared worse than high-school dropouts.

Some statistics suggest that the annual income of Americans with a college degree has fallen relative to that of high-school graduates for the first time in decades.

So, whereas the s were hardest on the lowest skilled, the s and this decade have squeezed people in the middle. The one truly continuous trend over the past 25 years has been towards greater concentration of income at the very top.

The scale of this shift is not visible from most popular measures of income or wages, as they do not break the distribution down finely enough.

But several recent studies have dissected tax records to investigate what goes on at the very top. The figures are startling. Put these pieces together and you do not have a picture of ever-widening inequality but of what Lawrence Katz of Harvard University, David Autor of the Massachusetts Institute of Technology and Melissa Kearney of the Brookings Institution call a polarisation of the labour market.

The bottom is no longer falling behind, the top is soaring ahead and the middle is under pressure. Can changes in technology explain this revised picture?

Up to a point. Computers and the internet have reduced the demand for routine jobs that demand only moderate skills, such as the work of bank clerks, while increasing the productivity of the highest-skilled.

Studies in Britain and Germany as well as America show that the pace of job growth since the early s has been slower in occupations that are easy to computerise.

For the most talented and skilled, technology has increased the potential market and thus their productivity. Top entertainers or sportsmen, for instance, now perform for a global audience.

Some economists believe that technology also explains the soaring pay of chief executives. One argument is that information technology has made top managers more mobile, since it no longer takes years to master the intricacies of any one industry.

As a result, the market for chief executives is bigger and their pay is bid up. Global firms plainly do compete globally for talent: Alcoa's boss is a Brazilian, Sony's chief executive is American and Welsh.

Documents Health and Medicine diseases Prostatitis. The transition towards a more preventive Medicine in a scenario of complex diseases demands a personalized diagnostic and treatment approaches, particularly those related to the use of medicaments.

The contribution of outstanding Clinical and Basic Pharmacology and Therapeutics Researchers in the academic program of the International Congress of Pharmacology Mexico highlights the key essence of 21st Century Pharmacology as an integrated and integrative science.

Sustainable development of Pharmacology and Therapeutics is a complex task that requires the cooperation of all parties involved.

Hereby we acknowledge the enthusiastic participation of higher education institutions, health care institutions, academic associations, government regulatory agencies, editorial and pharmaceutical companies whose cooperation made this meeting possible.

Our recognition to Dr. Enrique Graue Wiechers. Honorary President of the Meeting. Marco A. Directeur de Recherche 1. Enrique Hong Chong.

Augusto Bondani Guasti. Carolina Escobar. Alejandra Rosete. Carlos Castilo Henkel, Dr. Miguel Cervantes, Dr.

Carlos M. Esp Adic. Luis Solis Rojas. George Kunos. An approach to the current situation. Isabel Margarita Lugo Hubp.

Carlos Posadas Romero. Executive Director Clinical Pharmacology. Body fat disposition and cardiovascular risk.

Marcia Hiriart Urdanivia. Gerald Reaven. Rafael Villalobos-Molina. Jefe de la Division de Investigacion y Posgrado.

Unidad de Investigacion en Biomedicina. Abraham MajlufCruz. Serine Proteases et Pathologie Nerovasculaire.

Cyceron, Caen, France. Laurence Brunton. Enrique Hong Chong Dr. Enrique Hong Chong Panelists: Dr.

Gerald Reaven Dr. George Kunos Dr. Antoinette Maassen van den Brink. Antonio Caso Marasco. Armando Nevarez Sida.

Maribel Salas. Medical Director. CV Therapeutic Area. Safety Surveillance. Professor of Epidemiology.

Abraham Hartzema, the Perry A. Foote Eminent Scholar. Chris Delaney. Sanford H. Barsky Honorary Chairman: Dr. Iain L. Lisette M. Mario Mendez Acosta.

Department of Psychiatry. Achievements and challenges for Mexico. Luis Felipe Cortes. Bruno Escalante, M.

Professor and Director, Center for Cardiovascular Diseases. Pagano, Ph. Rosa Amalia Bobadilla MD.

Instituto Politecnico Nacional, Mexico D. John McGiff MD. New York Medical College. Carlos Maynor Salinas Santano.

Adah Almutairi, Ph. Eric Schopf, Ph. Jose Morachis, Ph. By Dra. Eugene Bratoeff. Buxton h Inmunoterapia: principios y aplicaciones.

Alicia Ortega. Buxton h Remembrance of Dr. Department of Biochemistry. Facultad de Medicina. A molecular point of view. Abraham Hartzema, Perry A.

Christopher Delaney. Teresa Montiel Montes. Oscar Galicia Castillo. Angelica 23 Zepeda Rivera. Guillermo Ceballos.

Ricardo Reyes Chilpa. Patricia Yahuaca Mendoza. Javier Lozoya. Georgina Araceli Torres Vargas. Isabel Saad Villegas.

Enrique Hong Chong, Dr. Laurence Brunton, and Dr. Castillo Henkel C. Ibarra and R. Villalobos-Molina 15 Pharmacological profile of the dopamine D2-like receptor subtypes mediating inhibition of the sympathetic vasopressor outflow in pithed rats Inna I.

Marichal Cancino, Alain H. Altamirano, Carlos M. Torres, V. Rocha L. Torres-Roque , A. Torres-Roque , E. Dibildox-Alvarado , A. Escobedo-Moratilla, G.

S Luevanos 1 1 1 Raymundo , M. Miranda-Beltran , P. Villalobos-Gutierrez 54 Antiinflammatory action of capsaicin on the brain endotoxinchallenged mice M.

S Luevanos Raymundo , P. Villalobos-Gutierrez M. Aguilar Carrasco , A. Carrasco2 Portugal and F. C and E. T , Medrano-Morales J.

Marquez-Delgado, Claudia A. Reyes-Estrada y Patricia Yahuaca-Mendoza. Almaguer-Vargas ; J. Bautista-Avila; H.

Although traditional 3 Mexican medicine utilizes approximately plants , most of these species have not been evaluated as sources of natural phenolic antioxidants.

The aim of this study was to determine the total phenolic content TPC and the total antioxidant capacity TAC of the methanolic extract of the flowers of Mantecoso Cercidium praecox , a plant used in Mexican folk medicine.

Plant material was collected in Oaxaca, Mexico, and extracted by standard 5 maceration process. A Green tea Camellia sinensis sample were purchased from an ordinary shop and subjected to the same 7 processes, since it is one of the richest sources of natural phenolic antioxidants.

The TPC values of C. Their TAC values were 1. The demonstration of the antioxidant activity and the phenolic content of C.

Although Mantecoso has lower TPC and TAC values than Green tea, it represents an interesting regional source of natural phenolic antioxidants, since the latter is barely consumed in non urban zones.

Acosta Gutierrez J. Nevertheless, the systemic delivery of IL-2 has been limited by its high toxicity. In this respect nanoparticles constitute an interesting tool for in situ IL-2 delivery.

Our work group has shown that several cervical cancer cells express, like lymphocytes, the IL-2 receptor IL-2R on their membranes.

Recently we have reported the construction of a nanocarrier structure that expresses non-covalently bound IL-2 on its external surface that renders the particle susceptible to be attached to IL-2R-bearing cells.

In order to evaluate the stability of our IL-2 nanocarrier particles, their physical integrity in different conditions of temperature, light and pH was determined using a cytometer for particle size and complexity.

Our results demonstrated that the nanocarrier presented a suitable stability as long as the buffering system pH stayed under control. Carrasco-Portugal and F.

Flores Murrieta. Dicloxacillin is a semi-synthetic penicillin that is widely used to treat a wide variety of bacterial infections including pneumonia, infections of the urinary tract and skin.

Currently, the reports about its pharmacokinetic information in humans are very scarce. The purpose of this study was to characterize the oral pharmacokinetics of dicloxacillin in Mexican female volunteers.

Eighteen female healthy volunteers aged All volunteers were fit according to medical history, medical examination and suitable laboratory tests.

The volunteers read the protocol approved by the institutional ethics and research committees and gave written informed consent for participation.

Plasma levels of the drug were determined using a high performance liquid chromatographic method developed in our laboratory and pharmacokinetic parameters were obtained by non-compartmental approach.

These results indicate that dicloxacilline is quickly absorbed and it has a short half-life, which is according to some previous reports.

Villahermosa, Tab. Cuernavaca, Mor. One herbalist and twelve diabetic patients were interviewed and they mainly mentioned the use of 12 plants for control diabetes.

Bibliographic review was made on line to complete the pharmacological information. The plants were botanically identified for a biologist as: Allium satirum ajo ; Matricaria recutita manzanilla ; Azadirachta indica A.

Juss neem ; Allium cep L. Other plants were mentioned for a great diversity of uses medicinal. The information on line indicated that these plants may be used for diabetes control too.

Male Wistar rats aged 14 weeks weight range, g were used. Thirty, 60 and 90 days after STZ injection, glycemia was again determined.

STZ, but not saline injection caused hyperglycemia. Our data suggest that the changes in the levels of blood glucose and body weight are depend of time and diabetes-induced STZ is a good model animal that it may be used for chronic studies.

Progesterone P4 has shown to preserve the functional integrity of the hippocampus in spite of a severe long-term 90 days loss of the pyramidal neuron population at CA1, and to prevent the progression of functional deficits after ischemia.

The aim of this study was to compare the CA1 pyramidal neuron population at 28 or 97 days after GCI, under treatment with P4 or its vehicle, to assess possible differences in the progression of neuronal damage after ischemia.

No differences were found at 28 vs 97 days in the CA1 pyramidal neuron population of the Sham group. The results suggest a progression of neuronal damage at CA1 in the absence of neuroprotective treatment after 28 days post-ischemia, and confirm previous observations that the functional integrity of the hippocampus may be preserved in P4- but not in Vehtreated rats, in spite of a severe neuronal loss in CA1.

The T. It was reported that N-propyl oxamate NPOx was inhibitor of HADH, however due to its polarity it cannot diffuse through the parasite membrane to exert the trypanocidal effect.

Both compounds were evaluated on the activity of the T. On the contrary the INC-5 strain was less susceptible to the action of these compounds.

Similar results were obtained with NPOx-B on cultured epimastigotes of both strains. These results demonstrate that the trypanocidal activity of these oxamates is a consequence of the energy metabolism decrease of this parasite.

This agrees with the NPOx-B hydrophobicity that allows it to cross biological barriers. Aguirre-Moreno AC.

Introduction: Ganoderma lucidum is a basidiomycete fungus that is used in traditional Chinese medicine. Polysaccharide and triterpene are two major categories of compounds purified of this species, which are attributed to its potent biological activity.

Studies have indicated that components of these extracts have a wide range of pharmacological actions including to the Central Nervous System.

Twenty four hours after the animals were transcardially perfused and their brain collected for histological and histochemical purposes.

Conclusions: Our results shows that GL protect against KA induced alterations of hippocampal cells and confirm the efficacy of the treatment, are an effective experimental tool to reduce the brain lesions associated with inflammatory responses.

The etiology of the disease is still unclear, and it is thought that PD may be caused by a combination of genetic and environmental factors.

In the search of new pharmacological options, statines have been recognized for their potential application in neurodegenerative disease.

In Mexico, the HTA held the ninth leading cause of death in , with a rate of The HTA is a public health problem, and is a disorder where the patient must wear a life-long treatment, so it is necessary to identify and monitor the use of drugs to improve the quality of prescribing, and as taking into account the limited public resources and the continuous increase of drug costs.

The evaluation of the use of antihypertensive drugs allows us to make more efficient investment spending, increase effectiveness and reduce damage in patients with the aim of improving the quality of life of hypertensive patients.

The health system must implement programs that improve the quality of care at a lower economic cost, and that hypertension has an impact on mortality in Mexico and worldwide.

A study of drug utilization with a crossover design in three different times , and The target population will be patients with hypertension outpatient and inpatient at a hospital in Mexico City.

A questionnaire was designed on purpose general data, factors that determine or influence the prescription number and type of medication.

The pharmacoepidemiology is a useful tool to learn how drugs are used to contribute to a more rational use and reduce the damage caused to patients.

Stroke is the third leading cause of death in major industrialized countries, and the first cause of motor disability and cognitive deficit.

Cerebral ischemia induces a wide range of clinic manifestations, such as motor incoordination, sensory, cognitive and behavioral deficits, which prevent patients to continue with their normal life style.

Bilateral sequential common carotid artery sectioning SCAS is a model developed in our laboratory; that produces a reproducible pattern of mortality, extensive brain damage and a wide range of measurable neurobehavioral alterations.

Thus, the aims of this work were to identify and describe alterations in learning and memory induced by SCAS on the elevated plus maze EPM performance and to evaluate the neuroprotective efficacy of dexrazoxane in reducing cognitive deficit.

For that purpose we used male CFW middle-aged weeks , mice were randomly assigned to three different groups: SCAS, sham or control group.

For the cognitive evaluation we used a modification to the procedure proposed by Itoh et al , i. Briefly, mice were trained 4 consecutive days to enter the reinforced arm, which was reinforced with a drop of sweetened milk.

All animals performed three trials per session, before basal , and 24, 48, 72 and 96 h after surgery. Our results showed that ischemic animals slept and groom more than sham animals after the surgery.

Cancer is a group of diseases with high incidence national and World wide. Most of the time the treatment for Cancer, is very expensive, sometimes toxic, and inefficient.

These medicinal plants are frequently used in a traditionally way. The plant was recollected from de Hidalgo state.

In this study were created two groups: One group was for control and the other one was for treatment.

Each one with 10 mice. The extract was administered oral every day till the mice died. The rodents form both groups were weighed every 48 hours and were registered the day they died.

The statistical evaluation from the data was realized for the anova test. It was observed the difference between the two groups with the Tukey test.

The Grow tumor was measure in grams and this one was smaller in treatment group as difference form the control group. The group treatments wash increment of the life time respect to the control group.

In the present work, the use of etanolic extract of Prunella Vulgaris wash partiality inhibited of the grow tumor, and prolongation of the life time.

Epidemiological data indicate that the disease is more prevalent in women; however experimental commonly used male rats for the diabetes type 2 DM2 evaluation.

For each case a control and diabetic group were formed. The water and food consumption were recorded daily in 4 rats samples of each group.

Urinary and blood samples on days 21, 28, 35, 42 and 48 were obtained for glucose, protein and ALAT concentration determination.

With these values, urinary flow, glucose clearance and diabetic rat percentage were calculated. Results: both cases DM2 rats with, showed a water and food intake increase as well as an urinary flow increase.

In female rats, a longer hyperglycemic state was observed even to 48 days compared with male rats even to 35 days.

The higher diabetic rat percentage was Cervical Cancer is the second major cause of death in women; actually there are few selective treatments to aboard the latest phases in the disease.

The present drugs have several side effects and they have a little selectivity function, it generates the necessity to develop new selective compounds to the cancer treatment.

It is known the Capsaicinoids and derivate have an antiproliferative effect in human cancer cell lines.

Newly capsaicinoides analogues attempt to find new compounds with apoptotic, and antiproliferative activity, as a selective function against the cancer cells.

In this work the apoptotic, antiproliferative, and cytotoxic activity of the Rinvanil an analogue of capsaicin was evaluated on cervical cancer cell lines HeLa, CaSk CaSki, and ViBo respectively.

However the ViBo cells are not affected in the cellular cycle. The cytotoxic effect indicate that Rinvanil affect in An increased level of active Caspase-3 was observed with the Rinvanil treatment in all the cell lines, indicating a apoptotic property.

Interesting Rinvanil does not have a cytotoxic effect, and eater does not affect to the proliferative potential in non tumoral cells fibroblastic and lymphocytic cells.

Ciudad Universitaria, Puebla, Pue. Certain saponins are bioactive compounds and have medical uses.

It has been reported that saponins have properties such as anticancer, hypocholesterolemic, hypoglycemic and anti-oxidant activity.

The diverse activity of saponins could be explained by its complexity of chemical natures. Structurally, saponin has a general backbone structure, a policyclic aglycone of either steroid or triterpenoid in nature.

Diosgenin is a steroidal sapogenin with estrogenic and antiproliferative activity and induce apoptosis in several cell lines.

In order to evaluate its antitumor activity, we determined their effect on cell proliferation, cell cycle, and cell death.

The cytotoxic effect of the compound on HeLa, CaSki, ViBo cell lines, and human lymphocytes was also evaluated; the results show a null effect on tumoral cells as on lymphocytes cells, implying that OH-Di-Glu is not cytotoxic.

The observation of apoptotic bodies as well as the increase in the expression of active caspase-3 along with the fragmentation of DNA, confirmed that OH-Di-Glu induced apoptosis in tumor cells.

Significantly, its antiproliferative activity on tumor cells did not affect the proliferative potential of peripheral blood lymphocytes.

The compound shows selective antitumor activity and therefore serves as promising lead candidate for further optimization.

Departamento de Neuroinmunologia. Even when their mechanism of protection have not been elucidated completely, it has been proposed that could be due to antioxidant properties related to an increase in the paraoxon-1 activity, making them a possible pharmacologic therapeutic option.

Animals body weight was recorded daily. These preliminary results show a neuroprotective effect of SIM against neurotoxicity induced by QUIN, which will be complemented with other studies.

Gabriel A. The Pt NMR spectrum indicates that a single type of platinum atom is present. Redox properties of these compounds have been investigated by cyclic voltammetry.

The increase of the length of the spacer arm in the ligand presents a favorable effect on the platinum complexes, diminishing their activation energy.

Among all the studied complexes [Pd 2 II TPHNCl2]Cl2 presented the highest antineoplasic activity in transformed lung cells, similar to the one shown by cisplatinum, i.

Furthermore, growth alterations, profile proteins changes; possibility the alteration of DNA originated by palladium complex it is reflects in quantitative decrease of proteins.

The results shown that palladium II complex, cause alterations at different cellular levels, we can assume that palladium II complex, might have different biological mechanism of action.

It becomes evident that the most careful and guided ligands selection is fundamental to obtain metallodrugs with anticancer property. Therefore, these enzymes can be used as biomarker.

A biomarker is a biologic characteristic that is measured and evaluated objectively as an indicator of normal biologic processes, pathogenic processes, or pharmacologic response to therapeutic intervention.

Typically these are immunohistochemical stains but, more recently, mRNA or protein. In this study we evaluated the expression of N-SMase and ceramidase in serum and kidney of diabetic rats at protein levels.

Methods: Experiments were performed in male Wistar rats weighing g. We evaluated the expression of N-SMase and ceramidase in serum and kidney of diabetic rats at protein levels by Western blot.

Conclusion: Expression of ceramidase in serum can be used as biomarker in diabetes. Arellano-Plancarte A. Although inosine was widely believe to be inert, in recent years has been demonstrated that inosine inhibits the release of proinflammatory cytokines and chemokines, and that exerts anti-inflammatory process, also several reports suggest a benefit effect of inosine on blood glucose levels and the inosine treatment appears to protect against the development of type 1 diabetes in a mouse model.

However despite the beneficial effect of inosine on glucose levels that has been proposed, at least one report suggests that when inosine is released after hypoxia activates hepatic glucose liberation having a hyperglycemic effect.

For this time the effect of inosine on glucose levels is controversial and the molecular mechanisms involved are still unknown.

The purpose of this work is to investigate in a hepatic cell line the effect of inosine on key proteins and events of the insulin signaling.

How inosine induces its effect and what proteins are involved are the questions that we are now trying to resolve.

Departament of Psychophysiology, Faculty of Psychology. Substantial evidence indicates that modafinil exerts its effects via presynaptic dopaminergic mechanisms, inhibits DA transporter DAT.

The purpose of the present study was to determine if AMPH was able to produce a dose dependent stimulus gradient and if Modafinil substitute the discriminative cue produced by AMPH.

Results: Discrimination test and substitution test data are expressed as the mean percentage of response on the drug-appropriate lever in each period with different doses of AMPH and modafinil and were analyzed with one-way ANOVA.

We found that AMPH was able to exert control over lever selection in the drug discrimination task by producing a dose dependent stimulus gradient.

Cancer is a group of diseases characterized by abnormal and uncontrolled growth of cells. Ethno-pharmacology has become a promising strategy for treatment human cancer.

In fact traditional medicine employs plants and herbs to stop the development of cancer. Furthermore, these plants have one of the main sources of active drugs for new cancer chemoprevention.

Kalanchoe sp. In this study, we investigated the cytotoxic effect of ethanolic, ethyl-acetate and hexane extracts of stems and leaves of Kalanchoe pinnata, Kalanchoe gastonis-bonnieri and Kalanchoe flammea by MTT and CV dying assay in various cancer cell lines.

As many natural occurring compounds are genotoxic, we evaluate the mutagenic properties with or without CYP metabolic activation, using a preincubation procedure of the Salmonella assay Ames test with strains TA98, TA and TA In dose dependent manner ethanol and ethyl-acetate extracts decrement the cell viability against lung A , colon HT29 , prostate PC3 and were not mutagenic on the Ames test.

Hexane extracts was not cytotoxic against these cell lines and were mutagenic on strains TA98 and TA In summary our data suggest that ethyl acetate extract of Kalanchoe flammea is a potential candidate to realize further studies about its phytochemical components and their mechanism of action in cancer cells.

Due to the need for new therapeutic strategies in alcoholic cirrhosis, we studied the effect of Crataegus oxyacantha whose antioxidant action has been described.

To determine the involvement of C. In alcoholic cirrhosis, LPox increased 3. GJIC decreased in alcoholic cirrhosis, evidenced by less transfer of Lucifer yellow, which was prevented by administering C.

These preliminary results support the potential usefulness of Crataegus oxyacantha phytotherapy to alleviate and prevent some alterations during the experimental alcoholic cirrhosis.

Universidad No. The aim of this work was to explore the AEs capabilility to induce proliferation of MCF-7 human breast cancer cells which is estrogen dependent.

Viability was estimated in metabolically active cells by the MTT assay. Their relative potency to E2 was: 90, 96, and 95 respectively.

Tamoxifen inhibited the AEs proliferative responses in a similar way to E2 suggesting the participation of the ER -8 -6 receptors in their proliferative action.

This response was not inhibited by tamoxifen indicating other mechanism involved in their antiproliferative response. Medical Research Unit in Neurological Diseases.

Specialty Hospital. The present study was carried out to determine the seizure susceptibility of Wistar Kyoto rats that normally show depressive-like behaviors.

Seizure activity was induced by daily administration of 3-mercaptopropionic acid 3-MP, The results obtained were compared with those from Wistar rats.

The statistical analysis revealed that WK animals presented high incidence of clonic seizures. Therefore, we conclude that the WKY strain is most susceptible to suffer seizures than Wistar strain.

UMF N. The presence of aged patients in the dental office is increasingly common, however it is important to note that this population suffers from multiple chronic diseases and use of several drugs at once.

To the extent that the dentist knows the physiological changes and comorbidities of these patients carry out a more timely and safe practice.

To determine the prevalence of chronic diseases and polypharmacy in older patients attending dental clinic in a primary care level. We did an observational descriptive crosssectional, 99 patients 60 years old and over attending dental clinic in , in an IMSS family medicine.

Last reviewed the medical notes of each patient in the information system of family medicine, were asked how many patients consumed daily medications, informed consent.

Variables: gender, age, number of chronic diseases and number of drugs that consumed time. The average was 3.

As observed comorbidity and polypharmacy favors older physiological capacities of elderly are decreased. In dental practice these aspects are rarely taken into account as the frequent use of AINES and antibiotics in this population as vulnerable can lead us to the presence of any adverse reactions.

Thus, this study was performed to investigate whether there is interaction between SMase and cPLA 2 signal transduction pathways and how this might contribute to the renal vascular response.

Methods: To evaluate the renal vascular response to exogenous SMase, experiments were performed on isolated perfused rat kidneys in the presence and absence of inhibitors of arachidonic acid metabolism.

Results: Exogenous SMase 0. Conclusion: Our results show that ceramide released by SMase activate cPLA2 to release AA, and hence the AA can be metabolized by COX pathway to form TXA2 in isolated perfused rat kidney, this signaling pathway represents a novel signal transduction mechanism for renal vasoconstriction.

Hospital de 4 Alta Especialidad Dr. Gustavo A. UNAM, D. Diabetic neuropathy is a common complication of diabetes that represents a major world health problem.

This type of pain is often characterized by stimulus-independent persistent pain or abnormal sensory perception of pain, such as allodynia and hyperalgesia.

Moreover, conventional analgesics that relieve acute pain cannot exert sufficient effects on neuropathic pain associated with diabetes and no potentially effective drug for treatment of this pain is currently available.

The aim of this work was to evaluate the effect of meloxicam and proglumide combination in diabetic neuropathy. The experiments were performance using male Wistar rats on weight g.

The paw withdrawal threshold was determined by the up-down method of Dixon and Chaplan et al. Allodynia was considered to be present when paw withdrawal thresholds were 4 g.

Streptozotocin injection caused hyperglycemia. Four weeks after diabetes induction Meloxicam and proglumide was evaluated in diabetic rats.

Moreover, meloxicam and proglumide combination diminished allodynia in diabetic rats. Briones-Aranda A. The 5-Hydroxytryptamine6 5-HT6 receptor has been implicated in the process of memory consolidation and associated with some aspects of the stress response regulation The aim of this study was to investigate, by the use of pharmacological tools, the implication of the 5HT6 receptor in the formation or consolidation of memory and how it can be affected by a prior exposure to acute stress.

The stressor employed was a modified version of the forced swimming test FS 24 hours before training.

The cognitive test used was a two trial novel object recognition task NORT. One-hundred and twenty male Wistar rats, weighing to grams, were divided into 12 groups.

The animals were trained and evaluated 24 hours later. The results show a decrease in the discrimination ratio of the previously stressed animals, an effect directly related to affected memory consolidation.

This effect was reversed by the administration of both agonists, but by neither of the antagonists of the 5-HT6 receptor. It is therefore likely that the effect of stress on cognitive processes is related to possible changes in the number and functioning of 5-HT6 receptors.

However, further research is necessary to explore this hypothesis. Weight reducing drugs like sibutramine and L-carnitine directly act on central nervious system CNS.

However, the effect of these drugs on serotonergic system of animals on hypoproteic diet is still unknown. Based on the above, the objective of the present study is to determine the effect of sibutramine and L-carnitine on 5-HIAA and GSH levels in brain regions of rat fed with low and normal protein diets.

The animals were distributed by chance in groups of 4 per diet, and were treated for 10 days as follows: group 1, saline solution NaCl 0.

All treatments were administered intraperitoneally. The animals were sacrificed by decapitation at the end of treatment, and their cerebrum, cortex, hemisphere, cerebellum, and medulla oblongata were extracted to determine the levels of glucose, glutathione GSH , lipid perioxidation Tbars , and 5-hydroxilindol acetic acid 5-HIAA.

Based on the results, it is suggested that sibutramine and L-carnitine induce biphasic antioxidant effect, and alter serotonergic metabolism in the brain regions of female rats under different nutritional conditions.

Some drugs that are clinically used in weight control, like sibutramine, act on the serotonergic metabolism, but its relation with zinc and free radical FR production in the CNS is still unknown.

Aim: To evaluate the effect of sibutramine and zinc on FR production. Results: The corporal weight and food consume were decreased in sibutramine plus zinc group.

TBARS decreased in cortex, hemispheres and medulla oblongata, likeness, GSH decreased in cortex, hemispheres and cerebellum by effect related to sibutramine group.

Zinc given alone and combined with sibutramine decreased H2O2 concentration in the cortex, hemispheres and cerebellum, but increased calcium and 5-HIAA concentration in all brain regions.

Our results suggest that sibutramine and zinc produce an antioxidant effect on different brain regions and both may be used to potential the control of food intake and lowering body weight in the clinical practice.

Calvillo M. Zenteno E. Heat shock proteins Hsps are expressed in response to several stress forms. Since the protein synthesis is increased, there is interest to investigate the Hsps role in pathology of Alzheimer disease AD.

It is known that Hsps interact directly with betasome one Hsps has been attributed lectinic activity i. The images were acquired with software IM of Leica microscopy.

The results show that inmunoreactivity levels in HsPs are increasing to respect to time of incubation when compared to control gruop.

It is known that C6 cells express high activity of synthesis and secretion of glycosaminoglycans. Proliferative and adhesive properties of the C6 are dependent on the expression of surface glycoproteins.

It was concluded that the stress modifies Hsps inmunoreactivity and sites whose recognized lectins are modified.

Biochemical determinations will be made to learn about the relationship between these proteins in vitro study.

These protective mechanisms have evolved over many years and have provided interesting chemicals that can be learned and incorporate in cosmeceuticals products.

Antioxidants are compounds that can eliminate ROS and protect the body from free radicals. It has aroused great interest in free radicals and its relation to cell aging.

This increased oxidative stress at the cellular level resulting in pathophysiological processes such as cancer, cardiovascular disease, neurodegenerative Alzheimer, Parkinson and cataracts.

Therefore, it is vitally important to find molecules that are able to minimize or prevent damage caused by free radicals.

To determine the antioxidant capacity of tlanchalagua Erythraea tetramera Schiede Plant extracts was obtained by reflux with different solvents for 6 hrs, then concentrated under reduced pressure yielding about 10 ml.

Different concentrations were prepared extracts and tested for antioxidant activity with ABTS 2. We evaluated the ability to capture free radicals by the ABTS assay of each extract.

There is a higher antioxidant capacity in the ethanol extract Phytochemical screening of methanolic extract showed flavonoids principally.

Conclusions: Ethanol extract was the most powerful, with Neonatal administration of monosodium glutamate MSG to mice causes neurotoxicity of the Central Nervous System CNS resulting in endocrine, metabolic and behavioral abnormalities.

On the other hand the amphetamine is a potent stimulant drug on CNS because it induced catecholamine released.

The control group was vehicle-treated only saline injections. The decreased susceptibility to the stimulant effects of amphetamine may occur as a consequence of changes in neural excitability, down regulation of dopamine-receptors, synthesis inhibition of catecholamines, or might be related to pharmacokinetics modifications, induced by neonatal treatment with MSG.

Homoeostasis is a dynamic equilibrium process adjustable to the age of organisms. When the cardiovascular system is disrupted, this is mismatched.

Which could be partially or totally attenuated, depending on age and life style. It is proposed that exercise could reduce cardiovascular risk.

The aim of the present work was to study the effect of treadmill training on systolic pressure SP , heart rate HR and ventricular hypertrophy VH in young and old male mice with heart injury induced by isoproterenol ISO.

ISO was administered 24h after last exercise session. SP and HR were measured weekly by the tail-cuff method. Young sedentary showed higher variation ranges on SP ISO treatment decreased SP Old sedentary and exercised showed no significant differences on the variation ranges on SP nor HR.

ISO decreased SP Moreover, this suggest that arterial pressure stabilization by exercise could protect from adverse effects of a heart injury independently of the age.

While the hypertrophy caused by heart injury could be accentuated in exercised young and attenuated in exercised old organisms.

The effects of training and heart injury on cardiovascular system are age differentially adjusted. Background: Psychiatric diseases have become a public health problem owing to their increased prevalence.

An option for their treatment is psychoactive medications, which are associated with multiple adverse effects. The purpose of this study was to determine the pharmacoepidemiology of psychoactive medication and the prevalence of psychiatric disease in adult patients seen at the Psychiatry Department at Durango General Hospital.

Methods: Clinical histories of the patients were reviewed for patients over 18 years of age that were seen at the outpatient clinic of the Psychiatry Department at Durango General Hospital that required psychoactive medication.

The study was conducted between January and February Results: The most commonly diagnosed conditions were the neurotic disorders, stress related disorders, and somatization disorders Seventy six percent of patients received more than one medication for their treatment.

The most commonly prescribed medications were the selective serotonin reuptake inhibitors, with Fluoxetine being the most prescribed medication Anxiolytics were the second most prescribed group, with Clonazepam being the most prescribed medication within this group Conclusions: Contrasting with the clinical practice guidelines, in which single drug therapy is recommended for most of the psychiatric diseases, only The age group with most prescriptions was between 30 and 59 years of age.

Torres , V. Uncontrolled high blood pressure increases the risk of heart disease, stroke, and kidney disease; it can also unnoticeably damage the heart, vessels, brain, and kidneys if not treated.

Some medicaments can control it. Diuretics, beta-blockers, ACE inhibitors and calcium channel blockers. But they have side effects.

In the laboratory of Dr. Two of these compounds one with morpholinic structure and the other with tiomorpholinic structure were used on glucose uptake of cardiomyocytes from hypertensive rats to characterize its heart protection properties.

Sodium, a major component of salt, can raise blood pressure by causing the body to retain fluid, which leads to a greater burden on the heart.

Increasing glucose uptake is a way of protecting the heart from hypoxic events and it is promoted by the glucose transporters Gluts.

We raised the blood pressure in these animals by administrating a high salt diet and observe that hypertension does not permit the metabolic switch that would protect the cardiac cells during hypoxia.

These compounds have successfully lowered the blood pressure and improved the metabolic state of cardiomyocytes from hypertensive animals as well as regulating the function of the glucose transporters.

Epilepsy is one of the most common neurological disorders. Oxidative stress due to generation of mitochondrial ROS is strongly implicated in seizures in the disorder.

It has been demonstrated that TPM modulate the antioxidant enzyme system and has features that make it attractive as a potential neuroprotective agent.

In this work, We explored, for the first time, the in vitro ROS scavenger activity of this drug. These results indicate that TPM possesses antioxidant in vitro potential.

The epilepsy is an alteration characterized by excessive electric activity of the brain. The study of this syndrome has derived in diverse experimental models.

One of these is the penicillin G intracerebral administration, in which has not yet determined whether benzodiazepine mu-opioid and muscarinic receptors are modified.

Aim: To evaluate the in vitro levels of union of the benzodiazepine, mu-opioid and muscarinic receptors in rat brain areas, during the interictal period after the repetitive administration of penicillin G into amygdala nucleus.

The electrographic recordings were realized before and after injection. The animals were sacrificed 24 h after last administration and the brains were processed with in vitro autoradiography studies and benzodiacepine, mu-opioid and muscarinic receptors were evaluated in different brain areas.

Results: The epileptic focus basolateral amigdalae nucleus was confirmed through an electrographic recording and was associated with behavioural changes.

However, the results in other brain areas are different. Conclusion: The benzodiazepine, mu-opioid and muscarinic receptors are involved in the seizures induced by intraamygdaline administration of penicillin G in rat.

Human temporal lobe epilepsy is a chronic neurological disease. The study of this pathology has derived in diverse experimental models, between them, the seizures induced by intraamygdaline administration of penicillin G.

However, the basic neurochemical mechanisms those underlying these convulsions are unknown. For this reason, we evaluated the in vivo extracellular levels of alanine, aspartate, glycine, glutamine, glutamate and taurine in the amygdalae epileptic focus, after the intracerebral repetitive administration of penicillin G.

The electrographic recordings of the ipsilateral and contralateral amygdalae were realized before and after injection.

In the 7th day last day of administration extracellular levels of neurotransmitters were evaluated in the epileptic focus through microdialysis studies.

Results: The epileptic focus basolateral amigdalae nucleus was confirmed through an electrographic recording. Aspartate had no change. Conclusion: Our results suggesting that the excitatory and inhibitory neurotransmitters are released during the seizures induced by intraamygdaline administration of penicillin G similarly to interictal changes that are observed in the human epileptic focus.

Its importance lies not only hyperglycemia, but in its consequences, increasing the risk of death from heart disease, cerebrovascular disease and renal failure, among others.

Since in type II diabetes has shown the presence of oxidative stress, is essential to study its relationship to some indicator that constitutes the most representative measurement of blood glucose: glycated hemoglobin.

Besides this, research on the abatement of oxidative stress represents a new fitomedication alternative adjunct in the management of DM.

We measured fasting glucose, Hb-A1 and oxidative stress markers among others, in the absence and presence of R. Related to this, lipoperoxidation increased significantly, which was prevented when the animals received the dose of extract of R.

This effect showed a modest decline in blood pressure and some metabolic disorders. The use of antioxidants as an alternative therapy for diabetes mellitus appears to be promising.

The mixture obtained contains importance as an agonist: therabaine, oripavine, erysodine whose concentration values are estimated in abundance by the chromatogram obtained.

The results shows that the seed is the part which contains a higher concentration of alkaloids followed by the corolla, and finally by the cup.

The more efficient extractions were obtained in the acidic compounds, which could be used as precursors of more potent substances to treat pain, like morphine, by other simplified routes.

The LD50 obtained is 3. The symptoms presented in the study group were paralysis of tail, hind limp prostration, convulsions, spasms and respiratory depression with hypothermia.

At concentration of Castillo-Henkel C. The aim of this paper is to analyze the changes of cyclooxygenase involvement in the contractile response to phenylephrine in the thoracic and abdominal aorta of prepubertal young and old rats.

During development there are changes in the activity of some enzymatic pathways, so particular in this work we analyze the change in the involvement of cyclooxygenase in the contractile effect of phenylephrine with age.

Cyclooxygenase is significantly involved in the release of prostanoids that regulate the effect of various agonists as in the case of phenylephrine, but not known that how this enzyme is involved during the development of the rat cardiovascular level.

In this experimental model we used male rats of 6, 16 weeks and 1 year of age. Then we proceeded to make concentration response curves to phenylephrine to M in the presence and absence of indomethacin COX antagonist.

Its has been shown in important way, that the relation between endothelia dysfunction and cardiovascular disease, however it has not related with vascular dysfunction associated to limb girdle muscular dystrophy and cardiopathy, in order to analyze the participation of the nitric oxide and prostacyclin on this experimental model of delta-sarcoglican null mice.

Finally we proceeded to make curves concentration response to -9 -5 -9 -6 acetilcoline 10 - 10 and sodium nitroprusiate 10 - We obtain differences in the coronary pressure and aorta relaxation with acethilcoline between Knock-out and wild type mice, in other hand the relaxation to sodium nitroprusiate not show differences in the thoracic aorta between knock-out and wild type mice, unlike we have differences in the coronary pressure with sodium nitropusiate.

Our results suggest changes in the relaxation independent of endothelium in artery coronary but not in thoracic aorta, although both vessels show differences in the relaxation dependent of endothelium.

Hypertension targets small and large arteries as well as organs, such as heart and kidney. Interestingly, captopril increased Ang II-induced pressor response in isolated kidney of SHR rats after 2 weeks treatment; whereas it diminished basal perfusion pressure in SHR rats 14 weeks after, and drastically reduced Ang II-elicited pressor response.

Data indicate that captopril influences both expression and function of AT 1 receptors in kidney of pre-hypertensive and adult SHR rats, probably avoiding AT1 receptor expression by blockade of angiotensin II synthesis.

The aim of the present study was to determine the prescribing practice for clozapine as well as the plasma levels of clozapine and its main metabolite norclozapine in Mexican patients.

A prospective study was performed in 69 in and out psychotic patients taking clozapine. Blood samples were taken at steady state.

Plasma concentrations of clozapine and norclozapine were determined by HPLC. Demographic variables as weight, gender and age were not significant.

Plasma levels showed a large interindividual variability and were significant higher in patients under treatment with fluoxetine.

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Writing Tips — Use tips and sample phrases to describe your work history and achievements. Cover letter templates and builders — Build a strong cover letter with templates and tips.

Design — Built-in resume templates take care of formatting and design. Resume samples — Compare your resume against samples.

Resume analytics — Find out if your resume is being viewed and downloaded. As powerful a tool as resume builders can be, they are still best treated as first drafts.

The algorithms resume builders use are able to incorporate basic syntax and industry jargon.

They do not, however, always sound natural. As Brenda Barron pointed out at business. Their overt function is to list your skills, experience, and education.

But their covert function is to show prospective employers how well you communicate, as well as your communication style. Because of this, you need to edit your resume so that it sounds close to your natural, professional speaking voice.

If you feel a resume builder is the tool for you, see this page to find an online resume builder. Starting off on the right foot.

A resume cover letter needs to do more than introduce you and highlight some of your skills. It needs to be engaging, well crafted, and well researched.

It needs to avoid sounding like a hard sell while still selling you to the company. If a resume is a list of your accomplishments, then its cover letter is where you get to tell the story of how you achieved those accomplishments.

Use it to explain how your experiences will benefit the company. Tell the potential employer why this job is important to you.

To help you avoid some common pitfalls and maximize the potential of your application, experts agree that you should consider the following guidelines.

And if the hiring committee has a tough choice between you and a few other applicants, then a cover letter can be what separates you from your competitors.

Keep it brief — And the shorter the better. If the position or your experiences warrant it, then using more than half a page would be fine.

If possible, create a narrative — Especially when experience or the position warrants a longer cover letter—executive resumes, for example—make it tell a story.

And the resolution could be getting this new job. Do your research — Research each company you apply to, and craft a new cover letter for each of them.

With social media, this is far easier than it used to be. Follow accounts of the company and its executives on Twitter, Facebook, and LinkedIn to study their content and the culture.

Focus on details — Make sure that every word is essential. Use a spelling and grammar checker and writing apps. Ask someone else to read it and give you advice.

Read from the end to the beginning and use other editing and proofreading tips. Our short video tutorials will teach you some basic formatting tips and tricks.

How to use paragraph styles and themes How to change header, footer, margins, and page size How to fit resume text on one page, and how to remove blank pages How to customize tabs, text boxes and tables How to add and remove sections.

We create our templates in Microsoft Office and we use Microsoft Word default fonts. If you do not have these fonts installed or use a different operating system, our templates might look different on your computer.

We use text styles and built-in color schemes to create our templates. Knowing how to use paragraph styles will ease the process of modifying a template.

While most resumes are US Letter size, some are A4. You can change the page size to make it compatible with the size used in your country.

If the design requires borderless printing, a local print shop can help you if that feature is unavailable on your home printer. All rights reserved.

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AnswerShark is an educational resource which provides homework answers to questions within various disciplines and subjects. The use of high-quality educational materials and professional sources supporting the arguments makes us different from competitors and a favorite among college and university students.

Our experts use fact-checked evidence and know how and where to find reliable sources to support their points of view. Our online homework helper experts aid students in understanding their assignments better especially in technical disciplines and are ready to complete advanced level projects.

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Use our online homework helper around the clock. Get rid of your headache and let us help you improve your grades. Health Promotion in Nursing Practice A BitTorrent file distribution consists of these entities: There are ideally many end users for a single file.

Start running a tracker or, more likely, have one running already. Start running an ordinary web server, such as apache, or have one already.

Associate the extension. Generate a metainfo. Put the metainfo file on the web server. Link to the metainfo. Start a downloader which already has the complete file the 'origin'.

Install BitTorrent or have done so already. Surf the web. Click on a link to a. Select where to save the file locally, or select a partial download to resume.

Wait for download to complete. Tell downloader to exit it keeps uploading until this happens. Metainfo files also known as. All strings in a.

The name key maps to a UTF-8 encoded string which is the suggested name to save the file or directory as. It is purely advisory. For the purposes of transfer, files are split into fixed-size pieces which are all the same length except for possibly the last one which may be truncated.

It is to be subdivided into strings of length 20, each of which is the SHA1 hash of the piece at the corresponding index.

There is also a key length or a key files , but not both or neither. If length is present then the download represents a single file, otherwise it represents a set of files which go in a directory structure.

In the single file case, length maps to the length of the file in bytes. For the purposes of the other keys, the multi-file case is treated as only having a single file by concatenating the files in the order they appear in the files list.

The files list is the value files maps to, and is a list of dictionaries containing the following keys: length - The length of the file, in bytes.

In the single file case, the name key is the name of a file, in the muliple file case, it's the name of a directory. Tracker GET requests have the following keys: The 20 byte sha1 hash of the bencoded form of the info value from the metainfo file.

This value will almost certainly have to be escaped. Note that this is a substring of the metainfo file. The info-hash must be the hash of the encoded form as found in the.

Conversely that means clients must either reject invalid metainfo files or extract the substring directly. They must not perform a decode-encode roundtrip on invalid data.

Each downloader generates its own id at random at the start of a new download. This value will also almost certainly have to be escaped. Generally used for the origin if it's on the same machine as the tracker.

Common behavior is for a downloader to try to listen on port and if that port is taken try , then , etc.

Note that this can't be computed from downloaded and the file length since it might be a resume, and there's a chance that some of the downloaded data failed an integrity check and had to be re-downloaded.

If not present, this is one of the announcements done at regular intervals. An announcement using started is sent when a download first begins, and one using completed is sent when the download is complete.

No completed is sent if the file was complete when started. Downloaders send an announcement using stopped when they cease downloading. Tracker responses are bencoded dictionaries.

If a tracker response has a key failure reason , then that maps to a human readable string which explains why the query failed, and no other keys are required.

Otherwise, it must have two keys: interval , which maps to the number of seconds the downloader should wait between regular rerequests, and peers.

Note that downloaders may rerequest on nonscheduled times if an event happens or they need more peers. More commonly is that trackers return a compact representation of the peer list, see BEP If you want to make any extensions to metainfo files or tracker queries, please coordinate with Bram Cohen to make sure that all extensions are done compatibly.

It is common to announce over a UDP tracker protocol as well. Peer connections are symmetrical.

Messages sent in both directions look the same, and data can flow in either direction. The peer protocol refers to pieces of the file by index as described in the metainfo file, starting at zero.

When a peer finishes downloading a piece and checks that the hash matches, it announces that it has that piece to all of its peers.

Connections contain two bits of state on either end: choked or not, and interested or not. Choking is a notification that no data will be sent until unchoking happens.

The reasoning and common techniques behind choking are explained later in this document. Data transfer takes place whenever one side is interested and the other side is not choking.

Interest state must be kept up to date at all times - whenever a downloader doesn't have something they currently would ask a peer for in unchoked, they must express lack of interest, despite being choked.

Implementing this properly is tricky, but makes it possible for downloaders to know which peers will start downloading immediately if unchoked.

Connections start out choked and not interested. When data is being transferred, downloaders should keep several piece requests queued up at once in order to get good TCP performance this is called 'pipelining'.

On the other side, requests which can't be written out to the TCP buffer immediately should be queued up in memory rather than kept in an application-level network buffer, so they can all be thrown out when a choke happens.

The peer wire protocol consists of a handshake followed by a never-ending stream of length-prefixed messages. The handshake starts with character ninteen decimal followed by the string 'BitTorrent protocol'.

The leading character is a length prefix, put there in the hope that other new protocols may do the same and thus be trivially distinguishable from each other.

All later integers sent in the protocol are encoded as four bytes big-endian. After the fixed headers come eight reserved bytes, which are all zero in all current implementations.

If you wish to extend the protocol using these bytes, please coordinate with Bram Cohen to make sure all extensions are done compatibly.

Next comes the 20 byte sha1 hash of the bencoded form of the info value from the metainfo file. If both sides don't send the same value, they sever the connection.

The one possible exception is if a downloader wants to do multiple downloads over a single port, they may wait for incoming connections to give a download hash first, and respond with the same one if it's in their list.

After the download hash comes the byte peer id which is reported in tracker requests and contained in peer lists in tracker responses.

If the receiving side's peer id doesn't match the one the initiating side expects, it severs the connection. That's it for handshaking, next comes an alternating stream of length prefixes and messages.

Messages of length zero are keepalives, and ignored. Keepalives are generally sent once every two minutes, but note that timeouts can be done much more quickly when data is expected.

All non-keepalive messages start with a single byte which gives their type. The possible values are: 'choke', 'unchoke', 'interested', and 'not interested' have no payload.

Its payload is a bitfield with each index that downloader has sent set to one and the rest set to zero. Downloaders which don't have anything yet may skip the 'bitfield' message.

The first byte of the bitfield corresponds to indices 0 - 7 from high bit to low bit, respectively. The next one , etc. Spare bits at the end are set to zero.

The 'have' message's payload is a single number, the index which that downloader just completed and checked the hash of.

The last two are byte offsets. Length is generally a power of two unless it gets truncated by the end of the file.

They are generally only sent towards the end of a download, during what's called 'endgame mode'. When a download is almost complete, there's a tendency for the last few pieces to all be downloaded off a single hosed modem line, taking a very long time.

To make sure the last few pieces come in quickly, once requests for all pieces a given downloader doesn't have yet are currently pending, it sends requests for everything to everyone it's downloading from.

To keep this from becoming horribly inefficient, it sends cancels to everyone else every time a piece arrives.

Note that they are correlated with request messages implicitly. Downloaders generally download pieces in random order, which does a reasonably good job of keeping them from having a strict subset or superset of the pieces of any of their peers.

Choking is done for several reasons. TCP congestion control behaves very poorly when sending over many connections at once. Also, choking lets each peer use a tit-for-tat-ish algorithm to ensure that they get a consistent download rate.

The choking algorithm described below is the currently deployed one. It is very important that all new algorithms work well both in a network consisting entirely of themselves and in a network consisting mostly of this one.

There are several criteria a good choking algorithm should meet. It should cap the number of simultaneous uploads for good TCP performance.

It should avoid choking and unchoking quickly, known as 'fibrillation'. It should reciprocate to peers who let it download.

Finally, it should try out unused connections once in a while to find out if they might be better than the currently used ones, known as optimistic unchoking.

The currently deployed choking algorithm avoids fibrillation by only changing who's choked once every ten seconds.

It does reciprocation and number of uploads capping by unchoking the four peers which it has the best download rates from and are interested.

Peers which have a better upload rate but aren't interested get unchoked and if they become interested the worst uploader gets choked.

If a downloader has a complete file, it uses its upload rate rather than its download rate to decide who to unchoke. For optimistic unchoking, at any one time there is a single peer which is unchoked regardless of its upload rate if interested, it counts as one of the four allowed downloaders.

Which peer is optimistically unchoked rotates every 30 seconds. To give them a decent chance of getting a complete piece to upload, new connections are three times as likely to start as the current optimistic unchoke as anywhere else in the rotation.

The BitTorrent Economics Paper outlines some request and choking algorithms clients should implement for optimal performance When developing a new implementation the Wireshark protocol analyzer and its dissectors for bittorrent can be useful to debug and compare with existing ones.

This document has been placed in the public domain. Singkat, Padat, dan Jelas Ingat bahwa perusahaan membutuhkan resume untuk mempercepat waktu mereka melakukan seleksi sebelum interview.

Oleh karena itu, waktu untuk melihat tiap resume juga sangat singkat menit sehingga resume yang kita buat harus benar benar padat dan jelas.

Untuk orang yang sudah mempunyai pengalaman kerja cukup lama, halaman masih bisa ditoleransi tetapi tetap usahakan dalam 1 halaman kecuali anda benar2 memiliki hal khusus yang perlu ditulis sebanyak itu.

Context Action Result CAR framework Ketika saya melihat resume dari beberapa orang dalam menulis pengalaman kerja, biasanya mereka hanya menulis judul dari pekerjaannya dan waktunya.

Contoh: - Sales Representative PT. Grosir Baju Indonesia - Dengan teknik penulisan seperti itu, apa yang bisa dilihat oleh perusahaan.

Perusahaan hanya tahu bahwa kita punya pengalaman menjadi sales representative selama 4 tahun dan sales supervisor selama 2 tahun di PT.

Grosir Baju Indonesia. Tetapi Perusahaan tidak akan pernah bisa melihat nilai lebih yang anda tawarkan.

Ketika mereka melihat resume dari kandidat lain mereka akan melihat hal yang sama. Bandingkan jika anda menulis seperti ini. Contoh Lain pengalaman sebagai programmer : - Membuat program akuntasi dengan cepat.

Telp, E-mail. Untuk Tempat tanggal lahir, biasanya tidak perlu dimasukkan karena orang akan sudah bisa mengetahui dari waktu anda menempuh pendidikan terakhir.

Tidak perlu mencantumkan daftar pendidikan mulai SD. Orang hanya tertarik untuk mengetahui pendidikan terakhir anda.

Untuk mengetahui contoh aplikasi teknik cara membuat resume bisa anda lihat di. Artikelnya sangat bermanfaat, terima kasih Admin untuk sharingnya.

Terima kasih infonya bro, sangat membatu saya.. Terimakasih untuk informasinya. Setidaknya dapat membantu dalam menambah wawasan kita.

Be Careful. Urus Pendirian PT. Urus Pendirian CV. Urus Ijin Prinsip dan perubahan. Urus Rekomendasi Departemen Perindustrian.

Urus Merk Dagang. Urus Ijin ISO Urus Pernikahan di Luar Negeri Beda Agama Dan masih banyak lagi perijinan lainnya untuk informasi lebih lanjut silahkan hubungi kami: atau.

How long did you walk your child to the door for school? Context : Macbeth is talking to the earth, in a soliloquy. Significance : There are several possible meanings to this quote.

If Macbeth is saying that sound will spoil the mood, then that is an example of metatheatre, which in a way, takes away from the gruesome details of the murder, as it somewhat breaks the forth wall and remind the listeners that Macbeth is only a character in a play.

This quote contains apostrophe, as Macbeth is talking to an inanimate object, and personification. Context : This quote is said by Macbeth to Lady Macbeth.

Macbeth had just killed Duncan, and he and Lady Macbeth are discussing what he had done. Macbeth is horrified and imagines voices that speak of his evildoings.

Macbeth will not sleep anymore. Later, Macbeth refers to himself using his three names, which could symbolize the three stages of his prophesy and his development.

Therefore, Glamis could symbolize his past self, which he was before he killed Duncan, Cawdor could symbolize his current self, which is who killed Duncan, and Macbeth could refer to his future self.

This follows the motif of three, as there were three witches and Hecate was commonly portrayed with three faces.

He feels very guilty, worried, and paranoid, so much as that he believes he will never be able to sleep again.

His sleep will disappear along with his innocence, as sleep is depicted as innocent and good. The witches punish people with lack of sleep, such as when they punished the sailor whose wife was mean with a lack of sleep.

This quote contains many metaphors. Context : This quote is said by Ross to an old man. They exchanging accounts of recent unnatural happenings.

It is the morning after Macbeth killed Duncan. Meaning : According to the clock, it is day, but darkness blocks the sun.

Is it dark because night has become more powerful than day, or because day is hiding its face in shame? People at this time believed that social standing was determined by God, so trying to usurp someone to put yourself in their place goes against the natural order of things.

Kings were believed to also have been chosen by divine powers, so killing and usurping Duncan was especially heinous.

The falcon could be representing King Duncan, while the owl, a bird often attributed to death, could represent witchcraft; therefore, this could be saying that witchcraft has killed Duncan.

Also, night, which can represent evil, is taking over day, which is good and supposed to be predominate. This quote contains personification and metaphors.

Context : Macbeth is talking to himself, in a soliloquy. I have ruined my peace for their benefit and given my soul to the devil to make them, the sons on Banquo, kings.

Instead of letting that happen, let fate come to the arena and fight me to the death. Macbeth, who committed evil deeds, will be punished, while Banquo, who has been good and loyal to the king, will be rewarded.

This quote also contains personification and metaphors. Context : Macbeth is speaking to Lady Macbeth. Meaning : We have hurt the snake, but have not killed it.

It is better to be with the dead, whom we have killed and put to rest in order to secure our peace, than to lie with tortured minds in a frenzy of sleeplessness.

He decides that he rather destroy the world than continue to live in fear, which indicates the reign of terror that Scotland will fall under.

Simply choose your favorite and get started. Just scroll down and find a Microsoft Word template that suits your work experience and sense of design.

Save time and effort — it does all of the writing and formatting for you. Click the button below and get started!

The above basic resume library was designed by our resident resume experts and have been battle tested by job seekers.

As this set performed the best, we included them in our resume builder software— and now we are offering them to you for free to download in Microsoft Word format.

Each professional template comes in five colors. Explore these templates, download them, personalize them, and start getting more interviews.

Resume Template Library 2: Advanced Layouts. Professional Brick Red. Timeless Dark Blue. Elegant 2. Modern Brick Red. Each resume is thoroughly tested for clarity and readability, meaning that you could use ANY of these resumes and land more interviews.

So have fun, and pick one that suits your sense of design. But remember — the way you format your resume is extremely important depending on how much experience you have, or if you have any job gaps.

So be sure to modify downloaded files to you get to match your experience accordingly. Template Library 3: Professional Profile Layouts.

Washington Brick Red. Murray Dark Blue. Trump Brick Red. Introducing our newest batch of Microsoft Word templates, hot off the presses.

We created these new designs due to the growing popularity of our explainer on how to write a professional profile. People interested in a layout featuring a PP introduction skyrocketed, so we toiled to create 8 brand new HR-approved documents for you to download for free.

Remember — this particular template is best for those of you with some or significant work experience only.

Template Library 4: Creative Layouts. Brooklyn Bridge Black. Taj Mahal Dark Blue. White House Brick Red. Empire State Gray.

Mount Rushmore Dark Blue. Are you having trouble separating yourself from your competitors? Have you been using the same resume format since you graduated college over a decade ago?

Then it might be time to add some style to your resume! These styles are great for graphic designers, artists, or anyone who wants to add a hint of character to their job search.

Job Hopper Original. Mid-Level Dark Blue. Career Changer Brick Red. Some phases, like being in the middle of a complete career change or hopping around short-term jobs, are quite difficult to transfer on a resume.

Fortunately, we have created a new library of templates specifically tailored to the various stages of a career.

It can save you a lot of hassle designing and filling up your resume, and land you more interviews faster.

Not Sure Which Template to Choose? The answer is yes — if you want to. Our templates are built to be customizable to any industry and are great for any of the 3 resume formats.

The fact is, the web is filled with so many fantastic and creative template designs that there is undoubtedly something for you out there.

Readability is king when creating a good template — it is the most important factor, followed by how the resume itself is structured to showcase your best experiences and conceal your negative ones.

Creating your own is fine, too. Wrong again. Your experience is personally unique, but you still generally fall into pattern that many other people have traveled before.

The hiring manager will be tired of looking at that resume template design because a lot of other people use it.

That hiring manager should be fired. We hope that clears up any misconceptions you may have had. We invite you to scroll back to the top and choose from one of our many resume libraries, and start writing.

Should i include collegiate sports in my resume? And if so where? It depends how much professional experience you have.

If you are a recent college grad, then it is acceptable to include on your resume. Good luck on the job hunt!

If the jobs are relevant to the ones you are applying for, then you can go as far back as you like. Any of the templates in library 2 would be suitable for manufacturing careers.

Best of luck! Multiple employers with jobs lasting two to three years each. The jobs have been similar, so the experience looks a bit repetitive.

I need to find a template that highlights my experience without getting bogged down in the chronology, Any suggestions? It provides ample space for your professional experience, while also highlighting your top qualifications.

How would I write that on my resume? Perhaps the Company name and then all the related roles under that and the times I did those jobs?

I was always the Executive Admin, but I did other jobs during that period. Yes, your suggestion is correct.

Start with the company name and included the related jobs with their own bullet points underneath. Good luck! Ive never had a job so what should I use?

Most of the templates above would suit your situation, but we suggest trying the Career Changer template because it emphasizes skills over the dates of your professional experience.

Good luck with grad school! Hope this helps! Good luck with the internship! Good Day Resume Genius. The skill I know is more on the medical.

What template should I use? Which is good for cabin crew applicant? I have no many work experience in service. So i want to highlight the other things.

Which template would you recommend for a career in education? Best of luck on the promotion! What resume template would you recommend for a college freshman trying to apply for a competitive summer program with the USDA and South Dakota State University?

Good luck with the summer program. Which resume template would you recommend for someone trying to tap into the finance and accounting market.

Looking for an entry-level position. Good luck with the job hunt. Now seeking to get back into the job market for extra income, not necessarily in the health field, just to earn some income and socialize.

What resume do you suggest? Good luck with your job search! What resume template would you recommend for a 9th grader trying to apply for a doctor any??

Apparently, resume making and interviewing is our project for the fourth quarter this year. Good luck on your project.

Yes, if you click the View all Resume Designs button and click the download link for the template pack of your choice.

Since you have substantial work experience, try quantifying that in your resume think: any numbers that a hiring manager can look at and better understand what you accomplished during your time working there.

Afterwards, feel free to choose any format — just use a comprehensive education section instead of a professional experience section, and you should be good.

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The rich are the big gainers in America's new prosperity. Add this article to your reading list by clicking this button.

The gap between rich and poor is bigger than in any other advanced country, but most people are unconcerned. Whereas Europeans fret about the way the economic pie is divided, Americans want to join the rich, not soak them.

Eight out of ten, more than anywhere else, believe that though you may start poor, if you work hard, you can make pots of money. It is a central part of the American Dream.

Thanks to a jump in productivity growth after , America's economy has outpaced other rich countries' for a decade. In the late s everybody shared in this boom.

Though incomes were rising fastest at the top, all workers' wages far outpaced inflation. But after something changed.

The pace of productivity growth has been rising again, but now it seems to be lifting fewer boats.

If you take into account the value of employee benefits, such as health care, the contrast is a little less stark. But, whatever the measure, it seems clear that only the most skilled workers have seen their pay packets swell much in the current economic expansion.

The fruits of productivity gains have been skewed towards the highest earners, and towards companies, whose profits have reached record levels as a share of GDP.

Even in a country that tolerates inequality, political consequences follow when the rising tide raises too few boats.

The impact of stagnant wages has been dulled by rising house prices, but still most Americans are unhappy about the economy.

The White House professes to be untroubled. He is right, but his claim is misleading, since the median worker—the one in the middle of the income range—has done less well than the average, whose gains are pulled up by the big increases of those at the top.

Privately, some policymakers admit that the recent trends have them worried, and not just because of the congressional elections in November.

The statistics suggest that the economic boom may fade. Americans still head to the shops with gusto, but it is falling savings rates and rising debts made possible by high house prices , not real income growth, that keep their wallets open.

A bust of some kind could lead to widespread political disaffection. Eventually, the country's social fabric could stretch.

America is nowhere near Brazil yet see chart 1. Despite a quarter century during which incomes have drifted ever farther apart, the distribution of wealth has remained remarkably stable.

The richest Americans now earn as big a share of overall income as they did a century ago see chart 2 , but their share of overall wealth is much lower.

Indeed, it has barely budged in the few past decades. The elites in the early years of the 20th century were living off the income generated by their accumulated fortunes.

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